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Instruments / Technical Area	Publication Details	Published	Actions
	Switching of receptor binding poses between closely related enteroviruses Daming Zhou , Ling Qin , Helen M. E. Duyvesteyn , Yuguang Zhao , Tzou-Yien Lin , Elizabeth E. Fry , Jingshan Ren , Kuan-Ying A. Huang , David I. Stuart Viruses 14 DOI: 10.3390/v14122625 Open Access Show Abstract ▼ Abstract: Echoviruses, for which there are currently no approved vaccines or drugs, are responsible for a range of human diseases, for example echovirus 11 (E11) is a major cause of serious neonatal morbidity and mortality. Decay-accelerating factor (DAF, also known as CD55) is an attachment receptor for E11. Here, we report the structure of the complex of E11 and the full-length ectodomain of DAF (short consensus repeats, SCRs, 1–4) at 3.1 Å determined by cryo-electron microscopy (cryo-EM). SCRs 3 and 4 of DAF interact with E11 at the southern rim of the canyon via the VP2 EF and VP3 BC loops. We also observe an unexpected interaction between the N-linked glycan (residue 95 of DAF) and the VP2 BC loop of E11. DAF is a receptor for at least 20 enteroviruses and we classify its binding patterns from reported DAF/virus complexes into two distinct positions and orientations, named as E6 and E11 poses. Whilst 60 DAF molecules can attach to the virion in the E6 pose, no more than 30 can attach to E11 due to steric restrictions. Analysis of the distinct modes of interaction and structure and sequence-based phylogenies suggests that the two modes evolved independently, with the E6 mode likely found earlier.	Nov 2022
I13-1-Coherence I13-2-Diamond Manchester Imaging	Multiscale characterization of the 3D network structure of metal carbides in a Ni superalloy by synchrotron X-ray microtomography and ptychography Zhiguo Zhang , Jia Chuan Khong , Billy Koe , Shifeng Luo , Shi Huang , Ling Qin , Silvia Cipiccia , Darren Batey , Andrew J. Bodey , Christoph Rau , Yu Lung Chiu , Zhu Zhang , Jean-Christophe Gebelin , Nick Green , Jiawei Mi Scripta Materialia 193, 71 - 76 DOI: 10.1016/j.scriptamat.2020.10.032 Diamond Proposal Number(s): [9974, 13488, 22525] Open Access Show Abstract ▼ Abstract: Synchrotron X-ray microtomography and ptychography were used to characterize the 3D network structure, morphology and distribution of metal carbides in an as-cast IN713LC Ni superalloy. MC typed carbides were found to distribute mainly on the grain boundary between the matrix γ and γ' phase. The differences in solidification cooling rate had a minor influence on the volume fraction of the MC type carbides, but significantly affected the carbide size, distribution and network morphology. Depending on the local composition of the remaining liquid phase and geometric constraints, the carbides can form either spherical or strip or network morphologies. The research demonstrated clearly the advantage and technical potential of using the two complementary tomography techniques synergistically to characterize non-destructively complex multiple-phase structures in three dimensional space with a spatial resolution of ~30 nm.	Oct 2020

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