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Instruments / Technical Area	Publication Details	Published	Actions
I22-Small angle scattering & Diffraction	Effects of ethylene oxide chain length on crystallization of polysorbate 80 and its related compounds Tania K. Lind , Emelie J. Nilsson , Benjamin Wyler , Dieter Scherer , Tatyana Skansberger , Maxim Morin , Vitaly Kocherbitov , Johan Engblom Journal Of Colloid And Interface Science 592, 468 - 484 DOI: 10.1016/j.jcis.2021.01.065 Diamond Proposal Number(s): [22299] Open Access Show Abstract ▼ Abstract: As a result of the synthesis protocol polyoxyethylene sorbitan monooleate (polysorbate 80, PS80) is a highly complex mixture of compounds. PS80 was therefore separated into its main constituents, e.g. polyoxyethylene isosorbide esters and polyoxyethylene esters, as well as mono- di- and polyesters using preparative high-performance liquid chromatography. In this comprehensive study the individual components and their ethoxylation level were verified by matrix assisted laser desorption/ionization time-of-flight and their thermotropic behavior was analyzed using differential scanning calorimetry and X-ray diffraction. A distinct correlation was found between the average length of the ethylene oxide (EO) chains in the headgroup and the individual compounds’ ability to crystallize. Importantly, a critical number of EO units required for crystallization of the headgroup was determined (6 EO units per chain or 24 per molecule). The investigation also revealed that the hydrocarbon tails only crystallize for polyoxyethylene sorbitan esters if saturated. PS80 is synthesized by reacting with approximately 20 mol of EO per mole of sorbitol, however, the number of EO units in the sorbitan ester in commercial PS80 products is higher than the expected 20 (5 EO units per chain). The complex behavior of all tested compounds revealed that if the amount of several of the linear by-products is reduced, the number of EO units in the chains will stay below the critical number and the product will not be able to crystallize by the EO chains.	Jun 2021

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I22-Small angle scattering & Diffraction

Effects of ethylene oxide chain length on crystallization of polysorbate 80 and its related compounds

Tania K. Lind , Emelie J. Nilsson , Benjamin Wyler , Dieter Scherer , Tatyana Skansberger , Maxim Morin , Vitaly Kocherbitov , Johan Engblom

Journal Of Colloid And Interface Science 592, 468 - 484

DOI: 10.1016/j.jcis.2021.01.065

Diamond Proposal Number(s): [22299]