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Instruments / Technical Area	Publication Details	Published	Actions
I19-Small Molecule Single Crystal Diffraction	Click amidations, esterifications and one–pot reactions catalyzed by Cu salts and multimetal–organic frameworks (M–MOFs) Rossella Greco , Estefanía Tiburcio , Brenda Palomar-De Lucas , Jesus Ferrando-Soria , Donatella Armentano , Emilio Pardo , Antonio Leyva-Pérez Molecular Catalysis 522 DOI: 10.1016/j.mcat.2022.112228 Diamond Proposal Number(s): [22411] Open Access Show Abstract ▼ Abstract: Amides and esters are prevalent chemicals in Nature, industry and academic laboratories. Thus, it is not surprising that a plethora of synthetic methods for these compounds has been developed along the years. However, these methods are not 100% atom economical and generally require harsh reagents or reaction conditions. Here we show a “spring–loaded”, 100% atom–efficient amidation and esterification protocol which consists in the ring opening of cyclopropenones with amines or alcohols. Some alkyl amines react spontaneously at room temperature in a variety of solvents and reaction conditions, including water at different pHs, while other alkyl amines, aromatic amines and alcohols react in the presence of catalytic amounts of simple Cu2+ salts or solids. A modular reactivity pattern (alkyl amines >> alkyl alcohols >> phenols >> aromatic amines) enables to design orthogonal and one–pot reactions on well–defined catalytic Multimetal–Organic Frameworks (M–MOFs, M= Cu, Ni, Pd), to easily functionalize the resulting cinnamides and cinnamic esters to more complex molecules. The strong resemblance of the amidation and esterification reaction conditions here reported with the copper–catalyzed azide–alkyne cycloaddition (CuAAC) allows to define this fast, clean and flexible protocol as a click reaction.	Apr 2022

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I19-Small Molecule Single Crystal Diffraction

Click amidations, esterifications and one–pot reactions catalyzed by Cu salts and multimetal–organic frameworks (M–MOFs)

Rossella Greco , Estefanía Tiburcio , Brenda Palomar-De Lucas , Jesus Ferrando-Soria , Donatella Armentano , Emilio Pardo , Antonio Leyva-Pérez

Molecular Catalysis 522

DOI: 10.1016/j.mcat.2022.112228

Diamond Proposal Number(s): [22411]