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14 items found (0 items not approved), displaying 1 to 10.[First/Prev] 1, 2 [Next/Last]

Instruments / Technical Area	Publication Details	Published
Detectors	Computational microscopy with the PERCIVAL detector system at TwinMic beamline Francesco Guzzi , Alessandra Gianoncelli , Luigi Stebel , Dario Giuressi , Giuseppe Cautero , Roberto Borghes , Iztok Gregori , Fulvio Billè , Martin Scarcia , Valentina Bonanni , Milan Žižić , Hyojung Hyun , William Nichols , Jonathan Correa , Alessandro Marras , Corenelia B. Wunderer , Heinz Graafsma , Ralf Hendrik Menk , George Kourousias Journal Of Instrumentation 20 DOI: 10.1088/1748-0221/20/01/C01032 Open Access Show Abstract ▼ Abstract: PERCIVAL is a novel soft X-ray detection system designed for the needs of modern microscopy. By integrating it into the TwinMic end-station at Elettra Sincrotrone Trieste, we conducted an exploratory computational microscopy experiment on biological samples, aiming at evaluating the entire system in a real use-case scenario. We present the methodology to convert the RAW data and our high-resolution image reconstructions.	Jan 2025
Detectors	The PERCIVAL detector: first user experiments J. Correa , M. Mehrjoo , R. Battistelli , F. Lehmkühler , A. Marras , C. B. Wunderer , T. Hirono , V. Felk , F. Krivan , S. Lange , I. Shevyakov , V. Vardanyan , M. Zimmer , M. Hoesch , K. Bagschik , N. Guerrini , B. Marsh , I. Sedgwick , G. Cautero , L. Stebel , D. Giuressi , R. H. Menk , A. Greer , T. Nicholls , W. Nichols , U. Pedersen , P. Shikhaliev , N. Tartoni , H. J. Hyun , S. H. Kim , S. Y. Park , K. S. Kim , F. Orsini , F. J. Iguaz , F. Büttner , B. Pfau , E. Plönjes , K. Kharitonov , M. Ruiz-Lopez , R. Pan , S. Gang , B. Keitel , H. Graafsma Journal Of Synchrotron Radiation 30, 242 - 250 DOI: 10.1107/S1600577522010347 Open Access Show Abstract ▼ Abstract: The PERCIVAL detector is a CMOS imager designed for the soft X-ray regime at photon sources. Although still in its final development phase, it has recently seen its first user experiments: ptychography at a free-electron laser, holographic imaging at a storage ring and preliminary tests on X-ray photon correlation spectroscopy. The detector performed remarkably well in terms of spatial resolution achievable in the sample plane, owing to its small pixel size, large active area and very large dynamic range; but also in terms of its frame rate, which is significantly faster than traditional CCDs. In particular, it is the combination of these features which makes PERCIVAL an attractive option for soft X-ray science.	Jan 2023
Detectors	Development of multi-element monolithic germanium detectors for X-ray detection at synchrotron facilities L. Manzanillas , S. Aplin , A. Balerna , P. Bell , J. Casas , M. Cascella , S. Chatterji , C. Cohen , G. Dennis , P. Fajardo , H. Graafsma , H. Hirsemann , F. J. Iguaz , K. Klementiev , T. Kołodziej , T. Martin , R. Menk , F. Orsini , M. Porro , M. Quispe , B. Schmitt , N. Tartoni , M. Turcato , C. Ward , E. Welter Nuclear Instruments And Methods In Physics Research Section A: Accelerators, Spectrometers, Detectors And Associated Equipment 1047 DOI: 10.1016/j.nima.2022.167904 Show Abstract ▼ Abstract: In past years efforts have concentrated on the development of arrays of Silicon Drift Detectors for X-ray spectroscopy. This is in stark contrast to the little effort that has been devoted to the improvement of germanium detectors, in particular for synchrotron applications. Germanium detectors have better energy resolution and are more efficient in detecting high energy photons than silicon detectors. In this context, the detector consortium of the European project LEAPS-INNOV has set an ambitious R&D program devoted to the development of a new generation of multi-element monolithic germanium detectors for X-ray detection. In order to improve the performance of the detector under development, simulations of the different detector design options have been performed. In this contribution, the efforts in terms of R&D are outlined with a focus on the modelization of the detector geometry and first performance results. These performance results show that a signal-to-background ratio larger than 1000 can be achieved in the energy range of interest from 5 keV to 100 keV.	Dec 2022
Detectors	XAFS-DET: A new high throughout X-ray spectroscopy detector system developed for synchrotron applications F. Orsini , S. Aplin , A. Balerna , P. Bell , J. Casas , M. Cascella , S. Chatterji , C. Cohen , G. Dennis , P. Fajardo , H. Graafsma , H. Hirsemann , F. J. Iguaz , K. Klementiev , T. Kołodziej , L. Manzanillas , T. Martin , R. Menk , M. Porro , M. Quispe , B. Schmitt , N. Tartoni , M. Turcato , C. Ward , E. Welter Nuclear Instruments And Methods In Physics Research Section A: Accelerators, Spectrometers, Detectors And Associated Equipment 67 DOI: 10.1016/j.nima.2022.167600 Show Abstract ▼ Abstract: The high brilliance and coherent beams resulting from recent upgraded synchrotron radiation facilities open the way for a large range of experiments, where detectors play a key role in the techniques and methods developed to fully exploit the upgraded synchrotron. For instance, one of the major limitations of XAFS experiment is the performance of the detectors. In order to be able to measure more challenging samples and to cope with the very high photon flux of the current and future (diffraction limited) sources, technological developments of detectors are necessary. In this framework, the germanium detector developed in the European project LEAPS-INNOV aims at improving several technological aspects. This type of detector represents a very important class of instruments for X-ray spectroscopy due to the fact that they enable to detect efficiently photons of considerable higher energy with respect to silicon detectors. The objective of this project consists in pushing the detector performance beyond the state-of-the-art. Preliminary layout and main choices for the design studies of this new detector are presented in this paper.	Oct 2022
Detectors	Characterization of the Percival detector with soft X-rays Alessandro Marras , Jonathan Correa , Sabine Lange , Vahagn Vardanyan , Tim Gerhardt , Manuela Kuhn , Frantisek Krivan , Igor Shevyakov , Manfred Zimmer , Moritz Hoesch , Kai Bagschik , Frank Scholz , Niccolo Guerrini , Ben Marsh , Iain Sedgwick , Giuseppe Cautero , Dario Giuressi , Gregori Iztok , Ralf H. Menk , Martin Scarcia , Luigi Stebel , Tim Nicholls , William Nichols , Ulrik K. Pedersen , Polad Shikhaliev , Nicola Tartoni , Hyojung Hyun , Seonghan Kim , Kyungsook Kim , Seungyu Rah , Arkadiusz Dawiec , Fabienne Orsini , Giovanni Pinaroli , Alan Greer , Steve Aplin , April D. Jewell , Todd J. Jones , Shouleh Nikzad , Michael E. Hoenk , Frank Okrent , Heinz Graafsma , Cornelia B. Wunderer Journal Of Synchrotron Radiation 28, 131 - 145 DOI: 10.1107/S1600577520013958 Open Access Show Abstract ▼ Abstract: In this paper the back-side-illuminated Percival 2-Megapixel (P2M) detector is presented, along with its characterization by means of optical and X-ray photons. For the first time, the response of the system to soft X-rays (250 eV to 1 keV) is presented. The main performance parameters of the first detector are measured, assessing the capabilities in terms of noise, dynamic range and single-photon discrimination capability. Present limitations and coming improvements are discussed.	Jan 2021
	Segmented flow generator for serial crystallography at the European X-ray free electron laser Austin Echelmeier , Jorvani Cruz Villarreal , Marc Messerschmidt , Daihyun Kim , Jesse D. Coe , Darren Thifault , Sabine Botha , Ana Egatz-Gomez , Sahir Gandhi , Gerrit Brehm , Chelsie E. Conrad , Debra T. Hansen , Caleb Madsen , Saša Bajt , J. Domingo Meza-Aguilar , Dominik Oberthuer , Max O. Wiedorn , Holger Fleckenstein , Derek Mendez , Juraj Knoška , Jose M. Martin-Garcia , Hao Hu , Stella Lisova , Aschkai Allahgoli , Yaroslav Gevorkov , Kartik Ayyer , Steve Aplin , Helen M. Ginn , Heinz Graafsma , Andrew J. Morgan , Dominic Greiffenberg , Alexander Klujev , Torsten Laurus , Jennifer Poehlsen , Ulrich Trunk , Davide Mezza , Bernd Schmitt , Manuela Kuhn , Raimund Fromme , Jolanta Sztuk-Dambietz , Natascha Raab , Steffen Hauf , Alessandro Silenzi , Thomas Michelat , Chen Xu , Cyril Danilevski , Andrea Parenti , Leonce Mekinda , Britta Weinhausen , Grant Mills , Patrik Vagovic , Yoonhee Kim , Henry Kirkwood , Richard Bean , Johan Bielecki , Stephan Stern , Klaus Giewekemeyer , Adam Round , Joachim Schulz , Katerina Dörner , Thomas D. Grant , Valerio Mariani , Anton Barty , Adrian P. Mancuso , Uwe Weierstall , John C. H. Spence , Henry N. Chapman , Nadia Zatsepin , Petra Fromme , Richard A. Kirian , Alexandra Ros Nature Communications 11 DOI: 10.1038/s41467-020-18156-7 Open Access Show Abstract ▼ Abstract: Serial femtosecond crystallography (SFX) with X-ray free electron lasers (XFELs) allows structure determination of membrane proteins and time-resolved crystallography. Common liquid sample delivery continuously jets the protein crystal suspension into the path of the XFEL, wasting a vast amount of sample due to the pulsed nature of all current XFEL sources. The European XFEL (EuXFEL) delivers femtosecond (fs) X-ray pulses in trains spaced 100 ms apart whereas pulses within trains are currently separated by 889 ns. Therefore, continuous sample delivery via fast jets wastes >99% of sample. Here, we introduce a microfluidic device delivering crystal laden droplets segmented with an immiscible oil reducing sample waste and demonstrate droplet injection at the EuXFEL compatible with high pressure liquid delivery of an SFX experiment. While achieving ~60% reduction in sample waste, we determine the structure of the enzyme 3-deoxy-D-manno-octulosonate-8-phosphate synthase from microcrystals delivered in droplets revealing distinct structural features not previously reported.	Sep 2020
Detectors	P2M: A 2MPixel CMOS image sensor for soft X-ray detection I. Sedgwick , F. Krivan , I. Shevyakov , M. Zimmer , H. Graafsma , G. Cautero , D. Giuressi , R. Menk , G. Pinaroli , L. Stebel , A. Greer , N. Guerrini , U. Pedersen , N. Tartoni , S. Y. Rah , H. J. Hyun , K. S. Kim , S. H. Kim , B. Boitrelle , F Orsini , B. Marsh , T. Nicholls , A. Marras , C. B. Wunderer , J. Correa , S. Lange , M. Kuhn 2019 26th IEEE International Conference on Electronics, Circuits and Systems (ICECS) DOI: 10.1109/ICECS46596.2019.8964996 Show Abstract ▼ Abstract: High brilliance synchrotrons and Free Electron Lasers (FELs) require high performing detector systems to realise their full potential. High dynamic range, low noise and high frame rate are all of great importance. In this paper we describe the P2M CMOS sensor, designed for soft X-ray detection at such facilities. We refer to previous work on test devices demonstrating a noise of <16e-, a full well capacity of >5Me- and quantum efficiency of >80% at 400eV (and with good sensitivity even below this value). Initial test results on the first Front Side Illuminated (FSI) 2 Megapixel device are also presented, and an outline of future work is described.	Nov 2019
Detectors	The Percival 2-Megapixel monolithic active pixel imager C. B. Wunderer , J. Correa , A. Marras , S. Aplin , B. Boitrelle , P. Goettlicher , F. Krivan , M. Kuhn , S. Lange , M. Niemann , F. Okrent , I. Shevyakov , M. Zimmer , N. Guerrini , B. Marsh , I. Sedgwick , G. Cautero , D. Giuressi , I. Gregori , G. Pinaroli , R. Menk , L. Stebel , A. Greer , T. Nicholls , U. K. Pedersen , N. Tartoni , H. Hyun , K. Kim , S. Rah , H. Graafsma Journal Of Instrumentation 14, C01006 - C01006 20th International Workshop On Radiation Imaging Detectors DOI: 10.1088/1748-0221/14/01/C01006 Show Abstract ▼ Abstract: The peak brilliance reached by today's Free-Electron Laser and Synchrotron light sources requires photon detectors matching their output intensity and other characteristics in order to fully realize the sources' potential. The Pixellated Energy Resolving CMOS Imager, Versatile And Large (Percival) is a dedicated soft X-ray imager (0.25–1 keV) developed for this purpose by a collaboration of DESY, Rutherford Appleton Laboratory/STFC, Elettra Sincrotrone Trieste, Diamond Light Source, and Pohang Accelerator Laboratory. Following several generations of prototypes, the Percival "P2M" 2-Megapixel imager—a 4.5×5 cm monolithic, stitched sensor with an uninterrupted imaging area of 4×4 cm2 (1408×1484 pixels of 27×27 μm—was produced and has demonstrated basic functionality with a first-light image using visible light. It is currently being brought to full operation in a front-illuminated configuration. The readout system being commissioned in parallel has been developed specifically for this imager which will produce—at full 300 Hz frame rate—data at 20 Gbit/s. A first wafer with eight Percival P2M chips has undergone backthinning to enable soft X-ray detection. It has been diced and chips are currently being wirebonded. We summarize here the P2M system, the project status, and show the P2M sensor's first response to visible light.	Jan 2019
I10-Beamline for Advanced Dichroism - scattering Detectors	Percival: A soft x-ray imager for synchrotron rings and free electron lasers Alessandro Marras , Cornelia Wunderer , Jonathan Correa , Benjamin Boitrelle , Peter Goettlicher , Manuela Kuhn , Frantisek Krivan , Sabine Lange , Frank Okrent , Igor Shevyakov , Joshua Supra , Maximilian Tennert , Manfred Zimmer , Niccola Guerrini , Ben Marsh , Iain Sedgwick , Giuseppe Cautero , Dario Giuressi , Anastasya Khromova , Ralf Menk , Giovanni Pinaroli , Luigi Stebel , Alan Greer , Tim Nicholls , Ulrik Pedersen , Nicola Tartoni , Hyo Jung Hyun , Kyung Sook Kim , Seung Yu Rah , Heinz Graafsma Proceedings of the 13th International Conference on Synchrotron Radiation Instrumentation – SRI2018 DOI: 10.1063/1.5084691 Show Abstract ▼ Abstract: In this paper, we are presenting the Percival detector, a monolithic CMOS Imager for detection of soft x-rays in Synchrotron Rings and Free Electron Lasers. The imager consists in a 2D array of many (2M) small (27um pitch) pixels, without dead or blind zones in the imaging area. The imager achieves low noise and high dynamic range by means of an adaptive-gain in-pixel circuitry, that has been validated on prototypes. The imager features on-chip Analogue-to-Digital conversion to 12+1 bits, and has a readout speed which is compatible with most of Free Electron Laser Facilities. For direct detection of low-energy x-rays, the imager is back-illuminated and post-processed to achieve 100% fill factor.	Jan 2019
I03-Macromolecular Crystallography	Megahertz serial crystallography Max O. Wiedorn , Dominik Oberthuer , Richard Bean , Robin Schubert , Nadine Werner , Brian Abbey , Martin Aepfelbacher , Luigi Adriano , Aschkan Allahgholi , Nasser Al-Qudami , Jakob Andreasson , Steve Aplin , Salah Awel , Kartik Ayyer , Saša Bajt , Imrich Barák , Sadia Bari , Johan Bielecki , Sabine Botha , Djelloul Boukhelef , Wolfgang Brehm , Sandor Brockhauser , Igor Cheviakov , Matthew A. Coleman , Francisco Cruz-Mazo , Cyril Danilevski , Connie Darmanin , R. Bruce Doak , Martin Domaracky , Katerina Dörner , Yang Du , Hans Fangohr , Holger Fleckenstein , Matthias Frank , Petra Fromme , Alfonso M. Gañán-Calvo , Yaroslav Gevorkov , Klaus Giewekemeyer , Helen Mary Ginn , Heinz Graafsma , Rita Graceffa , Dominic Greiffenberg , Lars Gumprecht , Peter Göttlicher , Janos Hajdu , Steffen Hauf , Michael Heymann , Susannah Holmes , Daniel A. Horke , Mark S. Hunter , Siegfried Imlau , Alexander Kaukher , Yoonhee Kim , Alexander Klyuev , Juraj Knoška , Bostjan Kobe , Manuela Kuhn , Christopher Kupitz , Jochen Küpper , Janine Mia Lahey-Rudolph , Torsten Laurus , Karoline Le Cong , Romain Letrun , P. Lourdu Xavier , Luis Maia , Filipe R. N. C. Maia , Valerio Mariani , Marc Messerschmidt , Markus Metz , Davide Mezza , Thomas Michelat , Grant Mills , Diana C. F. Monteiro , Andrew Morgan , Kerstin Mühlig , Anna Munke , Astrid Münnich , Julia Nette , Keith A. Nugent , Theresa Nuguid , Allen M. Orville , Suraj Pandey , Gisel Pena , Pablo Villanueva-Perez , Jennifer Poehlsen , Gianpietro Previtali , Lars Redecke , Winnie Maria Riekehr , Holger Rohde , Adam Round , Tatiana Safenreiter , Iosifina Sarrou , Tokushi Sato , Marius Schmidt , Bernd Schmitt , Robert Schönherr , Joachim Schulz , Jonas A. Sellberg , M. Marvin Seibert , Carolin Seuring , Megan L. Shelby , Robert L. Shoeman , Marcin Sikorski , Alessandro Silenzi , Claudiu A. Stan , Xintian Shi , Stephan Stern , Jola Sztuk-Dambietz , Janusz Szuba , Aleksandra Tolstikova , Martin Trebbin , Ulrich Trunk , Patrik Vagovic , Thomas Ve , Britta Weinhausen , Thomas A. White , Krzysztof Wrona , Chen Xu , Oleksandr Yefanov , Nadia Zatsepin , Jiaguo Zhang , Markus Perbandt , Adrian P. Mancuso , Christian Betzel , Henry Chapman , Anton Barty Nature Communications 9 DOI: 10.1038/s41467-018-06156-7 Open Access Show Abstract ▼ Abstract: The new European X-ray Free-Electron Laser is the first X-ray free-electron laser capable of delivering X-ray pulses with a megahertz inter-pulse spacing, more than four orders of magnitude higher than previously possible. However, to date, it has been unclear whether it would indeed be possible to measure high-quality diffraction data at megahertz pulse repetition rates. Here, we show that high-quality structures can indeed be obtained using currently available operating conditions at the European XFEL. We present two complete data sets, one from the well-known model system lysozyme and the other from a so far unknown complex of a β-lactamase from K. pneumoniae involved in antibiotic resistance. This result opens up megahertz serial femtosecond crystallography (SFX) as a tool for reliable structure determination, substrate screening and the efficient measurement of the evolution and dynamics of molecular structures using megahertz repetition rate pulses available at this new class of X-ray laser source.	Oct 2018

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