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Instruments / Technical Area	Publication Details	Published	Actions
I03-Macromolecular Crystallography	Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78 Magdalena Wisniewska , Tobias Karlberg , Lari Lehtiö , Ida Johansson , Tetyana Kotenyova , Martin Moche , Herwig Schuler Plos One 5 (1) DOI: 10.1371/journal.pone.0008625 PMID: 20072699 Diamond Proposal Number(s): [480] Open Access Show Abstract ▼ Abstract: The 70-kDa heat shock proteins (Hsp70) are chaperones with central roles in processes that involve polypeptide remodeling events. Hsp70 proteins consist of two major functional domains: an N-terminal nucleotide binding domain (NBD) with ATPase activity, and a C-terminal substrate binding domain (SBD). We present the first crystal structures of four human Hsp70 isoforms, those of the NBDs of HSPA1L, HSPA2, HSPA5 and HSPA6. As previously with Hsp70 family members, all four proteins crystallized in a closed cleft conformation, although a slight cleft opening through rotation of subdomain IIB was observed for the HSPA5-ADP complex. The structures presented here support the view that the NBDs of human Hsp70 function by conserved mechanisms and contribute little to isoform specificity, which instead is brought about by the SBDs and by accessory proteins.	Jan 2010
Accelerator Physics	Sapphire - a high peak brightness X-ray source as a possible option for a next generation UK light source R. Bartolini , C. Christou , J. H. Han , J. Kay , R. Walker EPAC08 proceedings Show Abstract ▼ Abstract: We present the results of initial studies of one option for a next generation UK light source, based on a normal conducting S-band linac and photocathode gun.	Jun 2008

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