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Instruments / Technical Area	Publication Details	Published	Actions
I13-2-Diamond Manchester Imaging	Nanoparticle contrast agents for dark-field X-ray imaging Carlos Navarrete-Leon , Adam Doherty , Margarita Strimaite , Joseph C. Bear , Alessandro Olivo , Marco Endrizzi , P. Stephen Patrick Nano Letters DOI: 10.1021/acs.nanolett.4c04878 Diamond Proposal Number(s): [30748] Open Access Show Abstract ▼ Abstract: The poor soft tissue contrast of X-ray CT necessitates contrast agent use to improve diagnosis across disease applications, yet their poor detection sensitivity requires high injected doses, which restrict use in at-risk populations. Dark-field X-ray imaging is emerging as a more sensitive alternative to traditional attenuation-based imaging, leveraging scattered radiation to produce contrast. Yet aside from large, short-lived microbubbles, the alternate physics of dark-field detection has yet to be exploited for contrast agent development. Here we demonstrate that high-Z nanoparticles can provide a new means to producing dark-field image contrast, promoting scatter via a higher rather than lower electron density compared to microbubbles, increasing detection sensitivity compared to attenuation-based detection of a clinical iodine-based agent at an equivalent X-ray dose. As the use of dark-field X-ray imaging expands into more common clinical usage, this will support the development of a new class of nanoparticulate contrast agents.	Nov 2024

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I13-2-Diamond Manchester Imaging

Nanoparticle contrast agents for dark-field X-ray imaging

Carlos Navarrete-Leon , Adam Doherty , Margarita Strimaite , Joseph C. Bear , Alessandro Olivo , Marco Endrizzi , P. Stephen Patrick

Nano Letters

DOI: 10.1021/acs.nanolett.4c04878

Diamond Proposal Number(s): [30748]