Diamond Publications - Search Results

Search Again...

These results only include publications that have been reviewed and processed by Diamond Light Source. To also view papers that have not yet been processed click here.

You can use the folder icon under Actions to collate papers as required. You can then click on View Folder in the left-hand navigation to review and/or download your folder.

One item found (0 items not approved).

Instruments / Technical Area	Publication Details	Published	Actions
Krios II-Titan Krios II at Diamond	Aviadenovirus structure: A highly thermostable capsid in the absence of stabilizing proteins Marta Perez-Illana , Anna Schachner , Mercedes Hernando-Perez , Gabriela N. Condezo , Alberto Paradela , Marta Martínez , Roberto Marabini , Michael Hess , Carmen San Martín Plos Pathogens 21 DOI: 10.1371/journal.ppat.1013553 Diamond Proposal Number(s): [15997] Open Access Show Abstract ▼ Abstract: High-resolution structural studies have mainly focused on two out of the six adenovirus genera: mastadenoviruses and atadenoviruses. Here we report the high-resolution structure of an aviadenovirus, the poultry pathogen fowl adenovirus serotype 4 (FAdV-C4). FAdV-C4 virions are highly thermostable, despite lacking minor coat and core proteins shown to stabilize the mast- and atadenovirus particles, having no genus-specific cementing proteins, and packaging a 25% longer genome. Unique structural features of the FAdV-C4 hexon include a large insertion at the trimer equatorial region, and a long N-terminal tail. Protein IIIa conformation is closer to atadenoviruses than to mastadenoviruses, while protein VIII diverges from all previously reported structures. We interpret these differences in light of adenovirus evolution. Finally, we discuss the possible role of core composition in determining capsid stability properties. These results enlarge our view on the structural diversity of adenoviruses, and provide useful information to counteract fowl pathogens or use non-human adenoviruses as vectors.	Oct 2025

Instruments / Technical Area

Publication Details

Published

Actions

Krios II-Titan Krios II at Diamond

Aviadenovirus structure: A highly thermostable capsid in the absence of stabilizing proteins

Marta Perez-Illana , Anna Schachner , Mercedes Hernando-Perez , Gabriela N. Condezo , Alberto Paradela , Marta Martínez , Roberto Marabini , Michael Hess , Carmen San Martín

Plos Pathogens 21

DOI: 10.1371/journal.ppat.1013553

Diamond Proposal Number(s): [15997]