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Instruments / Technical Area	Publication Details	Published	Actions
I10-Beamline for Advanced Dichroism	Evidence of Redox-Active Iron Formation Following Aggregation of Ferrihydrite and the Alzheimers Disease Peptide β-Amyloid James Everett , Eva Céspedes , Leigh Shelford , Chris Exley , Joanna Collingwood , Jon Dobson , Gerrit Van Der Laan , Catherine A. Jenkins , Elke Arenholz , Neil Telling Inorganic Chemistry 53 (6), 2803−2809 DOI: 10.1021/ic402406g Diamond Proposal Number(s): [7670, 8731] Open Access Show Abstract ▼ Abstract: Recent work has demonstrated increased levels of redox-active iron biominerals in Alzheimer’s disease (AD) tissue. However, the origin, nature, and role of iron in AD pathology remains unclear. Using X-ray absorption, X-ray microspectroscopy, and electron microscopy techniques, we examined interactions between the AD peptide β-amyloid (Aβ) and ferrihydrite, which is the ferric form taken when iron is stored in humans. We report that Aβ is capable of reducing ferrihydrite to a pure iron(II) mineral WHERE antiferromagnetically ordered Fe2+ cations occupy two nonequivalent crystal symmetry sites. Examination of these iron(II) phases following air exposure revealed a material consistent with the iron(II)-rich mineral magnetite. These results demonstrate the capability of Aβ to induce the redox-active biominerals reported in AD tissue from natural iron precursors. Such interactions between Aβ and ferrihydrite shed light upon the processes of AD pathogenesis, while providing potential targets for future therapies.	Feb 2014

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I10-Beamline for Advanced Dichroism

Evidence of Redox-Active Iron Formation Following Aggregation of Ferrihydrite and the Alzheimers Disease Peptide β-Amyloid

James Everett , Eva Céspedes , Leigh Shelford , Chris Exley , Joanna Collingwood , Jon Dobson , Gerrit Van Der Laan , Catherine A. Jenkins , Elke Arenholz , Neil Telling

Inorganic Chemistry 53 (6), 2803−2809

DOI: 10.1021/ic402406g

Diamond Proposal Number(s): [7670, 8731]