I12-JEEP: Joint Engineering, Environmental and Processing
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Nolwenn
Le Gall
,
Fabio
Arzilli
,
Giuseppe
La Spina
,
Margherita
Polacci
,
Biao
Cai
,
Margaret E.
Hartley
,
Nghia T.
Vo
,
Robert C.
Atwood
,
Danilo
Di Genova
,
Sara
Nonni
,
Edward W.
Llewellin
,
Mike R.
Burton
,
Peter D.
Lee
Diamond Proposal Number(s):
[12392]
Abstract: Crystallisation is a complex process that significantly affects the rheology of magma, and thus the flow dynamics during a volcanic eruption. For example, the evolution of crystal fraction, size and shape has a strong impact on the surface crust formation of a lava flow, and accessing such information is essential for accurate modelling of lava flow dynamics. To investigate the role of crystallisation kinetics on lava flow behaviour, we performed real-time, in situ synchrotron X-ray microtomography, studying the influence of temperature-time paths on the nucleation and growth of clinopyroxene and plagioclase in an oxidised, nominally anhydrous basaltic magma. Crystallisation experiments were performed at atmospheric pressure in air and temperatures from 1250 °C to 1100 °C, using a bespoke high-temperature resistance furnace. Depending on the cooling regime (single step versus continuous), two different crystal phases (either clinopyroxene or plagioclase) were produced, and we quantified their growth from both global and individual 3D texture analyses. The textural evolution of charges suggests that suppression of crystal nucleation is due to changes in the melt composition with increasing undercooling and time. Using existing viscosity models, we inferred the effect of crystals on the viscosity evolution of our crystal-bearing samples to trace changes in rheological behaviour during lava emplacement. We observe that under continuous cooling, both the onsets of the pāhoehoe-‘a‘ā transition and of non-Newtonian behaviour occur within a shorter time frame. With varying both temperature and time, we also either reproduced or approached the clinopyroxene and plagioclase phenocryst abundances and compositions of the Etna lava used as starting material, demonstrating that real-time synchrotron X-ray tomography is an ideal approach to unravel the final solidification history of basaltic lavas. This imaging technology has indeed the potential to provide input into lava flow models and hence our ability to forecast volcanic hazards.
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Aug 2021
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William
Liu
,
Salida
Mirzoeva
,
Ye
Yuan
,
Junjing
Deng
,
Si
Chen
,
Barry
Lai
,
Stefan
Vogt
,
Karna
Shah
,
Rahul
Shroff
,
Reiner
Bleher
,
Qiaoling
Jin
,
Nghia
Vo
,
Remon
Bazak
,
Carissa
Ritner
,
Stanley
Gutionov
,
Sumita
Raha
,
Julia
Sedlmair
,
Carol
Hirschmugl
,
Chris
Jacobsen
,
Tatjana
Paunesku
,
John
Kalapurkal
,
Gayle E.
Woloschak
Open Access
Abstract: Background: Neuroblastoma is the most common extracranial solid malignancy in childhood which, despite the current progress in radiotherapy and chemotherapy protocols, still has a high mortality rate in high risk tumors. Nanomedicine offers excit- ing and unexploited opportunities to overcome the shortcomings of conventional medicine. The photocatalytic properties of Fe O core-TiO shell nanocomposites and
3 4 2
their potential for cell specific targeting suggest that nanoconstructs produced using
Fe3O4 core-TiO2 shell nanocomposites could be used to enhance radiation effects in neuroblastoma. In this study, we evaluated bare, metaiodobenzylguanidine (MIBG) and 3,4-Dihydroxyphenylacetic acid (DOPAC) coated Fe3O4@TiO2 as potential radiosensitiz- ers for neuroblastoma in vitro.
Results: The uptake of bare and MIBG coated nanocomposites modestly sensitized neuroblastoma cells to ionizing radiation. Conversely, cells exposed to DOPAC coated nanocomposites exhibited a five-fold enhanced sensitivity to radiation, increased numbers of radiation induced DNA double-strand breaks, and apoptotic cell death. The addition of a peptide mimic of the epidermal growth factor (EGF) to nanoconju- gates coated with MIBG altered their intracellular distribution. Cryo X-ray fluorescence microscopy tomography of frozen hydrated cells treated with these nanoconjugates revealed cytoplasmic as well as nuclear distribution of the nanoconstructs.
Conclusions: The intracellular distribution pattern of different nanoconjugates used in this study was different for different nanoconjugate surface molecules. Cells exposed to DOPAC covered nanoconjugates showed the smallest nanoconjugate uptake,
with the most prominent pattern of large intracellular aggregates. Interestingly, cells treated with this nanoconjugate also showed the most pronounced radiosensitiza- tion effect in combination with the external beam x-ray irradiation. Further studies
are necessary to evaluate mechanistic basis for this increased radiosensitization effect. Preliminary studies with the nanoparticles carrying an EGF mimicking peptide showed.
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May 2021
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I12-JEEP: Joint Engineering, Environmental and Processing
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Diamond Proposal Number(s):
[22109, 24740, 14033, 19526, 21999]
Open Access
Abstract: Parallel-beam tomography systems at synchrotron facilities have limited field of view (FOV) determined by the available beam size and detector system coverage. Scanning the full size of samples bigger than the FOV requires various data acquisition schemes such as grid scan, 360-degree scan with offset center-of-rotation (COR), helical scan, or combinations of these schemes. Though straightforward to implement, these scanning techniques have not often been used due to the lack of software and methods to process such types of data in an easy and automated fashion. The ease of use and automation is critical at synchrotron facilities where using visual inspection in data processing steps such as image stitching, COR determination, or helical data conversion is impractical due to the large size of datasets. Here, we provide methods and their implementations in a Python package, named Algotom, for not only processing such data types but also with the highest quality possible. The efficiency and ease of use of these tools can help to extend applications of parallel-beam tomography systems.
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May 2021
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I12-JEEP: Joint Engineering, Environmental and Processing
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Diamond Proposal Number(s):
[21334]
Open Access
Abstract: Numerous aspects of early hominin biology remain debated or simply unknown. However, recent developments in high-resolution imaging techniques have opened new avenues in the field of paleoanthropology. More specifically, X-ray synchrotron-based analytical imaging techniques have the potential to provide crucial details on the ontogeny, physiology, biomechanics, and biological identity of fossil specimens. Here we present preliminary results of our X-ray synchrotron-based investigation of the skull of the 3.67-million-year-old Australopithecus specimen StW 573 (‘Little Foot’) at the I12 beamline of the Diamond Light Source (United Kingdom). Besides showing fine details of the enamel (i.e., hypoplasias) and cementum (i.e., incremental lines), as well as of the cranial bone microarchitecture (e.g., diploic channels), our synchrotron-based investigation reveals for the first time the 3D spatial organization of the Haversian systems in the mandibular symphysis of an early hominin.
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Mar 2021
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I13-2-Diamond Manchester Imaging
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Diamond Proposal Number(s):
[13704, 18197]
Open Access
Abstract: The torsional performance of bi-axially braided carbon fibre reinforced polymer (CFRP) tubes as a function of braid architecture is investigated. It is found that for a given braid pattern, the 45° braided CFRP tubes have higher shear moduli and lower shear strength than the 35° braids. In general, 2/2 (regular) braided CFRP tubes exhibit both higher shear strength and higher shear modulus than 1/1 (diamond) braids. However, beyond the peak load, the shear strength of 2/2 braided CFRPs exhibits sudden, steep drops, resulting in a lower remnant shear strength than 1/1 structures after the shear strain exceeds 4.5%. Moreover, the damage evolution is monitored in-situ by synchrotron X-ray computed tomography during torsional straining. It showed that for a 2/2 structure, inter-tow debonded regions are vertically interconnected allowing rapid crack propagation and strength drops, whereas for the 1/1 braid they are distributed in a chequer board causing more gradual loss of strength. The fibre/matrix interfacial strength and tow cross-over density play key roles in the torsional failure of 1/1 and 2/2 braided CFRP tubes, as the former controls damage initiation and the latter controls damage propagation.
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Sep 2020
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I12-JEEP: Joint Engineering, Environmental and Processing
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Diamond Proposal Number(s):
[16676]
Open Access
Abstract: Solute transport in unsaturated porous materials is a complex process, which exhibits some distinct features differentiating it from transport under saturated conditions. These features emerge mostly due to the different transport time scales at different regions of the flow network, which can be classified into flowing and stagnant regions, predominantly controlled by advection and diffusion, respectively. Under unsaturated conditions, the solute breakthrough curves show early arrivals and very long tails, and this type of transport is usually referred to as non-Fickian. This study directly characterizes transport through an unsaturated porous medium in three spatial dimensions at the resolution of 3.25 μm and the time resolution of 6 s. Using advanced high-speed, high-spatial resolution, synchrotron-based X-ray computed microtomography (sCT) we obtained detailed information on solute transport through a glass bead packing at different saturations. A large experimental dataset (>50 TB) was produced, while imaging the evolution of the solute concentration with time at any given point within the field of view. We show that the fluids’ topology has a critical signature on the non-Fickian transport, which yet needs to be included in the Darcy-scale solute transport models. The three-dimensional (3D) results show that the fully mixing assumption at the pore scale is not valid, and even after injection of several pore volumes the concentration field at the pore scale is not uniform. Additionally, results demonstrate that dispersivity is changing with saturation, being twofold larger at the saturation of 0.52 compared to that at the fully saturated domain.
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Sep 2020
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I12-JEEP: Joint Engineering, Environmental and Processing
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Diamond Proposal Number(s):
[12631, 13764, 19216]
Abstract: A key technique for controlling solidification microstructures is magneto-hydrodynamics (MHD), resulting from imposing a magnetic field to solidifying metals and alloys. Applications range from bulk stirring to flow control and turbulence damping via the induced Lorentz force. Over the past two decades the Lorentz force caused by the interaction of thermoelectric currents and the magnetic field, a MHD phenomenon known as Thermoelectric Magnetohydrodynamics (TEMHD), was also shown to drive inter-dendritic flow altering microstructural evolution. In this contribution, high-speed synchrotron X-ray tomography and computational simulation are coupled to reveal the evolution, dynamics and mechanisms of solidification within a magnetic field, resolving the complex interplay and competing flow effects arising from Lorentz forces of different origins. The study enabled us to reveal the mechanisms disrupting the traditional columnar dendritic solidification microstructure, ranging from an Archimedes screw-like structure, to one with a highly refined dendritic primary array. We also demonstrate that alloy composition can be tailored to increase or decrease the influence of MHD depending on the Seebeck coefficient and relative density of the primary phase and interdendritic liquid. This work paves the way towards novel computational and experimental methods of exploiting and optimising the application of MHD in solidification processes, together with the calculated design of novel alloys that utilise these forces.
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Jun 2020
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I13-2-Diamond Manchester Imaging
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Diamond Proposal Number(s):
[13704, 18197]
Abstract: Here we present the first real-time three dimension (3D) observations of damage evolution in a composite tube under torsion. An in-situ torsion test of 1/1 45° (diamond) braided carbon fibre-epoxy circular composite tube was performed on a loading rig and the damage process was characterised by synchrotron X-ray computed tomography (CT). A number of damage modes and their damage sequence has been identified and monitored globally and in more detail within a representative region of interest. In particular, intra-tow cracks and inter-tow debonding have been found to occur almost simultaneously at low shear strains (1.5%). It is noteworthy that inter-tow debonding was initially trapped/limited within repeated braid units before propagating and connecting with other damage modes in 3D. The area fraction of inter-tow debonds was quantified at different stages and it was found to dramatically increase with increasing shear strain beyond 1.5%. The total volume fraction of the observed intra-tow cracks of various forms was seen to grow rapidly beyond shear strain of 2.0%. Beyond the peak shear stress (at shear strain of 2.5%), fibre micro-buckling and kink bands occur in the tows subjected to torsion induced axial compression at crimped regions close to tow crossovers. Tow crossovers control many aspects of damage propagation under torsion, positively by localising inter-tow debonds and negatively by initiating fibre micro-buckling.
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Dec 2019
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I12-JEEP: Joint Engineering, Environmental and Processing
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Fabio
Arzilli
,
Giuseppe
La Spina
,
Mike R.
Burton
,
Margherita
Polacci
,
Nolwenn
Le Gall
,
Margaret E.
Hartley
,
Danilo
Di Genova
,
Biao
Cai
,
Nghia T.
Vo
,
Emily C.
Bamber
,
Sara
Nonni
,
Robert
Atwood
,
Edward W.
Llewellin
,
Richard A.
Brooker
,
Heidy M.
Mader
,
Peter D.
Lee
Diamond Proposal Number(s):
[16188]
Abstract: Basaltic eruptions are the most common form of volcanism on Earth and planetary bodies. The low viscosity of basaltic magmas inhibits fragmentation, which favours effusive and lava-fountaining activity, yet highly explosive, hazardous basaltic eruptions occur. The processes that promote fragmentation of basaltic magma remain unclear and are subject to debate. Here we used a numerical conduit model to show that a rapid magma ascent during explosive eruptions produces a large undercooling. In situ experiments revealed that undercooling drives exceptionally rapid (in minutes) crystallization, which induces a step change in viscosity that triggers magma fragmentation. The experimentally produced textures are consistent with basaltic Plinian eruption products. We applied a numerical model to investigate basaltic magma fragmentation over a wide parameter space and found that all basaltic volcanoes have the potential to produce highly explosive eruptions. The critical requirements are initial magma temperatures lower than 1,100 °C to reach a syn-eruptive crystal content of over 30 vol%, and thus a magma viscosity around 105 Pa s, which our results suggest is the minimum viscosity required for the fragmentation of fast ascending basaltic magmas. These temperature, crystal content and viscosity requirements reveal how typically effusive basaltic volcanoes can produce unexpected highly explosive and hazardous eruptions.
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Oct 2019
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I12-JEEP: Joint Engineering, Environmental and Processing
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Open Access
Abstract: X-Ray parallel-beam micro-tomography systems at synchrotron facilities are mainly bespoke designs. Technical problems from a detector system can strongly affect the quality of reconstruction results. Radial lens distortion in the visible light optics causes streak artifacts which get stronger towards the edge of the image. The irregular response of the detector gives rise to a variety of stripe artifacts in the sonogram; full stripes, partial stripes, fluctuating stripes, and unresponsive stripes. These give rise to ring artifacts of different kinds in the reconstructed image. The scattering of the scintillation photons can cause artifacts which are similar to beam hardening artifacts and reduce the resolution of the image. Here we present our practical approaches to tackle each such problem. These approaches are easy to implement and have low computational cost. The algorithms are freely available as open-source software.
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Sep 2019
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