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B21-High Throughput SAXS B23-Circular Dichroism	Structurally plastic peptide capsules for synthetic antimicrobial viruses Valeria Castelletto , Emiliana De Santis , Hasan Alkassem , Baptiste Lamarre , James Noble , Santanu Ray , Angelo Bella , Jonathan R. Burns , Bart W. Hoogenboom , Maxim G. Ryadnov Chemical Science DOI: 10.1039/C5SC03260A Diamond Proposal Number(s): [10083] Open Access Show Abstract ▼ Abstract: A conceptual design for artificial antimicrobial viruses is described. The design emulates viral assembly and function to create self-assembling peptide capsules that promote efficient gene delivery and silencing in mammalian cells. Unlike viruses, however, the capsules are antimicrobial, which allows them to exhibit a dual biological function: gene transport and antimicrobial activity. Unlike other antimicrobials, the capsules act as pre-concentrated antimicrobial agents that elicit rapid and localised membrane-disrupting responses by converting into individual pores at their precise landing positions on membranes. The concept holds promise for engineering virus-like scaffolds with biologically tuneable properties.	Dec 2015

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