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Instruments / Technical Area	Publication Details	Published	Actions
B23-Circular Dichroism	Interactions of GFAP with ceftriaxone and phenytoin: SRCD and molecular docking and dynamic simulation Paolo Ruzza , Rosa Maria Vitale , Rohanah Hussain , Barbara Biondi , Pietro Amodeo , Gianpietro Sechi , Giuliano Siligardi Biochimica Et Biophysica Acta (bba) - General Subjects DOI: 10.1016/j.bbagen.2016.04.021 Diamond Proposal Number(s): [8034] Open Access Show Abstract ▼ Abstract: GFAP is the major intermediate filament protein in mature astrocytes. Its increased expression and aggregation was firstly associated to Alexander's disease, and successively in different neurological diseases including scrapie, Alzheimer's and Creutzfeld–Jacob diseases. Recently, ceftriaxone a multi-potent β-lactam antibiotic able to overcome the blood–brain barrier, successfully eliminated the cellular toxic effects of misfolded mutated GFAP, similarly to phenytoin sodium, in a cellular model of Alexander's disease and inhibited α-synuclein aggregation protecting PC12 cells from the exposure to 6-hydroxydopamine.	May 2016

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