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Instruments / Technical Area	Publication Details	Published	Actions
I16-Materials and Magnetism	A phase diagram of the P3HT:PCBM organic photovoltaic system: implications for device processing and performance Paul E. Hopkinson , Paul A. Staniec , Andrew J. Pearson , Alan D. F. Dunbar , Tao Wang , Anthony J. Ryan , Richard A. L. Jones , David G. Lidzey , Athene M. Donald Macromolecules 44 (8) DOI: 10.1021/ma102524a Diamond Proposal Number(s): [1203] Show Abstract ▼ Abstract: This paper describes the construction of a phase diagram for the as-cast state in the organic photovoltaic system P3HT:PCBM. Evidence for a transition to a phase-separated state at PCBM concentrations greater than 70 wt % is seen both by DMTA and GIWAXS, and the glass transition temperatures of blends in the single phase state below 70 wt % PCBM are observed to be raised compared to the pure polymer. Pure PCBM is observed to exhibit a thermal transition at 155 °C, an observation unreported to date-offering insight into crystallites commonly seen in device films. The liquid-crystal phase of P3HT is shown to persist in the presence of up to 41 wt % PCBM. In addition, pure PCBM is shown to be significantly hygroscopic, with important implications for the processing of high-performance devices.	Mar 2011
I18-Microfocus Spectroscopy	Spherulites of amyloid-beta42 in vitro and in Alzheimer's disease Christopher Exley , Emily House , Joanna Collingwood , Mark R. Davidson , Danielle Cannon , Athene M. Donald Journal Of Alzheimers Disease 20 DOI: 10.3233/JAD-2010-091630 PMID: 20413877 Show Abstract ▼ Abstract: Several amyloidogenic proteins including insulin, ?-lactoglobulin, and albumin form spherulites in vitro under non-physiological conditions. These micrometer-sized, roughly spherical structures are composed of ordered arrays of amyloid fibrils in radial arrangements which, characteristically, show a typical Maltese cross pattern of light extinction under the polarizing microscope. The physiological significance of amyloid spherulites is unknown though in Alzheimer's disease, senile plaques composed primarily of ? sheets of amyloid-? (A?){42} have, very occasionally, been shown to give a Maltese cross pattern of light extinction under crossed polarizers. Herein we describe the first observation of the formation in vitro of spherulites of A?{42}. They were formed under near-physiological conditions in which the ? sheet conformation of pre-formed aggregates of A?{42} had been abolished following the addition of an excess of copper. Incubation of these preparations at 37°C for up to 9 months resulted in the formation of globular structures, 5–20 ?m in diameter, which exhibited a Maltese cross pattern of light extinction typical of spherulites. Near-identical spherulitic structures were also observed in abundance in 30 ?m thick sections of Alzheimer's disease brain tissue. Synchrotron x-ray fluorescence showed that the location of these spherulites in AD tissue coincided with locally elevated concentrations of tissue copper. The formation in vitro of spherulites of A?{42} which morphologically appeared analogous to spherulitic structures observed in vivo strongly supports the hypothesis that spherulites and senile plaques in AD tissue are one and the same structures and that their ultimate formation may involve copper.	Jul 2010

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