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Instruments / Technical Area	Publication Details	Published
B21-High Throughput SAXS I22-Small angle scattering & Diffraction	Flexibility defines structure in crystals of amphiphilic DNA nanostars Ryan Brady , Will T. Kaufhold , Nicholas J. Brooks , Vito Foderà , Lorenzo Di Michele Journal Of Physics: Condensed Matter 31 DOI: 10.1088/1361-648X/aaf4a1 Diamond Proposal Number(s): [17271, 16970] Show Abstract ▼ Abstract: DNA nanostructures with programmable shape and interactions can be used as building blocks for the self-assembly of crystalline materials with prescribed nanoscale features, holding a vast technological potential. Structural rigidity and bond directionality have been recognised as key design features for DNA motifs to sustain long-range order in 3D, but the practical challenges associated with prescribing building-block geometry with sufficient accuracy have limited the variety of available designs. We have recently introduced a novel platform for the one-pot preparation of crystalline DNA frameworks supported by a combination of Watson–Crick base pairing and hydrophobic forces (Brady et al 2017 Nano Lett. 17 3276–81). Here we use small angle x-ray scattering and coarse-grained molecular simulations to demonstrate that, as opposed to available all-DNA approaches, amphiphilic motifs do not rely on structural rigidity to support long-range order. Instead, the flexibility of amphiphilic DNA building-blocks is a crucial feature for successful crystallisation.	Feb 2019
I22-Small angle scattering & Diffraction	An amphiphilic-DNA platform for the design of crystalline frameworks with programmable structure and functionality Ryan A. Brady , Nicholas J. Brooks , Vito Foderà , Pietro Cicuta , Lorenzo Di Michele Journal Of The American Chemical Society DOI: 10.1021/jacs.8b09143 Diamond Proposal Number(s): [17271, 19371] Show Abstract ▼ Abstract: The reliable preparation of functional, ordered, nanostructured frameworks would be a game changer for many emerging technologies, from energy storage to nanomedicine. Underpinned by the excellent molecular recognition of nucleic acids, along with their facile synthesis and breadth of available functionalizations, DNA Nanotechnology is widely acknowledged as a prime route for the rational design of nanostructured materials. Yet, the preparation of crystalline DNA frameworks with programmable structure and functionality remains a challenge. Here we demonstrate the potential of simple amphiphilic DNA motifs, dubbed C-stars, as a versatile platform for the design of programmable DNA crystals. In contrast to all-DNA materials, in which structure depends on the precise molecular details of individual build-ing blocks, the self-assembly of C-stars is controlled uniquely by their topology and symmetry. Exploiting this robust self-assembly principle we design a range of topologically identical, but structurally and chemically distinct C-stars that following a one-pot reaction self- assemble into highly porous, functional, crystalline frameworks. Simple design variations allow us to fine-tune the lattice parameter and thus control the partitioning of macromolecules within the frameworks, embed responsive motifs that can induce isothermal disassembly, and include chemical moieties to capture target proteins specifically and reversibly.	Oct 2018
I22-Small angle scattering & Diffraction	Crystallization of Amphiphilic DNA C-Stars Ryan A. Brady , Nicholas J. Brooks , Pietro Cicuta , Lorenzo Di Michele Nano Letters DOI: 10.1021/acs.nanolett.7b00980 Diamond Proposal Number(s): [14217, 15030, 15530] Open Access Show Abstract ▼ Abstract: Many emerging technologies require materials with well-defined 3D nanoscale architectures. Production of these structures is currently underpinned by self-assembling amphiphilic macromolecules or engineered all-DNA building blocks. Both these approaches produce restricted ranges of crystal geometries due to synthetic amphiphiles’ simple shape and limited specificity, or the technical difficulties in designing space-filling DNA motifs with targeted shapes. We have overcome these limitations with amphiphilic DNA-nanostructures, or “C-Stars”, that combine the design freedom and facile functionalization of DNA-based materials with robust hydrophobic interactions. C-Stars self-assemble into single crystals exceeding 40 μm in size with lattice parameters exceeding 20 nm.	Apr 2017

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