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Instruments / Technical Area	Publication Details	Published	Actions
B22-Multimode InfraRed imaging And Microspectroscopy	Investigation of blood vessels in glioblastoma at a micrometric scale: a comparative study by synchrotron and conventional micro-FTIR Katia Wehbe , Adrian Travo , Sandrine Eimer , Gianfelice Cinque , Emmanuelle Barron , Gerard Deleris , Isabelle Forfar Analytical Methods DOI: 10.1039/c3ay41449c Diamond Proposal Number(s): [6019] Open Access Show Abstract ▼ Abstract: Glioblastoma, the most malignant brain tumor in humans, is characterized by being severely angiogenic and an increase in vascularization generally worsens the prognosis of patients. Finding the best approach to characterize glioma blood vessels (BVs) is very important in view of helping to determine any specific biomolecular markers of these tumors. In previous work by conventional FTIR spectroscopy we were able to discriminate some molecular markers in order to differentiate between normal and tumor BVs in glioma tissue sections. The aim of the present study was to assess whether FTIR microspectroscopy using a synchrotron radiation (SR) source could provide advantages over a classical globar IR source for detailed spectral analysis on such small features like micro-BVs. Using chemometric analysis such as PCA and HCA, the results show that a high brilliant SR beam provides a very satisfying quality signal compared with the globar source to study spectral images for relevant analysis of glioma big and micro-BVs and determination of subtle molecular markers characterizing them from the surrounding tissue.	Oct 2013

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B22-Multimode InfraRed imaging And Microspectroscopy

Investigation of blood vessels in glioblastoma at a micrometric scale: a comparative study by synchrotron and conventional micro-FTIR

Katia Wehbe , Adrian Travo , Sandrine Eimer , Gianfelice Cinque , Emmanuelle Barron , Gerard Deleris , Isabelle Forfar

Analytical Methods

DOI: 10.1039/c3ay41449c

Diamond Proposal Number(s): [6019]