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Instruments / Technical Area	Publication Details	Published
B16-Test Beamline Optics	3D Medipix2 detector characterization with a micro-focused X-ray beam E. N. Gimenez-navarro , J. Marchal , K. J. S. Sawhney , L. Alianelli , M. Lozano , Giulio Pellegrini , C. Fleta , V. O'shea , R. Bates , C. Parkes , A. Mac Raighne , D. Maneuski , N. Tartoni IWORID 2009- International Workshop on Radiation Imaging Detectors DOI: 10.1016/j.nima.2010.06.140 Diamond Proposal Number(s): [520] Show Abstract ▼ Abstract: Three-dimensional (3D) photodiode detectors offer advantages over standard planar photodiodes in a wide range of applications. The main advantage of these sensors for X-ray imaging is their reduced charge sharing between adjacent pixels, which could improve spatial and spectral resolution. However, a drawback of 3D sensors structures is the loss of detection efficiency due to the presence in the pixel structure of heavily doped electrode columns which are insensitive to X-ray. In this work two types of 3D silicon detectors: n-type wafer with hole collecting readout-columns (n-type) and p-type wafer with electron collecting readout-columns (p-type), bump-bounded to a Medipix2 read-out chip were characterized with a 14.5 keV micro-focused X-ray beam from a synchrotron. Measurements of the detection efficiency and the charge sharing were performed at different bias voltages and Medipix2 energy thresholds and compared with those of a standard planar silicon sensor.	Jul 2010
B22-Multimode InfraRed imaging And Microspectroscopy	FTIR microspectroscopy of stained cells and tissues. Application in cancer diagnosis Jacek Pijanka , Nick Stone , Gianfelice Cinque , Ying Yang , Achim Kohler , Katia Wehbe , Mark Frogley , Gary Parkes , Joanna Parkes , Paul Dumas , Daniel Van Pittius , Christophe Sandt , Gillian Douce , Dhruvananda Sockalingum , Josep Sulé-suso Spectroscopy 24, 73-78 DOI: 10.3233/SPE-2010-0419 Diamond Proposal Number(s): [2390] Show Abstract ▼ Abstract: It is widely accepted that FTIR spectroscopy has a huge potential in cancer diagnosis. However further work is required to bring this technique into pathology departments. One of the areas where big efforts will be required is the development of cell spectra databases to be used in the diagnosis of cancer. Presently, unstained cytology and tissue samples are studied with FTIR spectroscopy. However, it is not always possible to identify in unstained samples the types of cells present. In order to achieve this, samples need staining after FTIR spectra have been obtained. We have recently shown it is possible to obtain FTIR spectra of stained cells using a synchrotron source (10.1038/labinvest.2010.8). This allows recording FTIR spectra from cells already characterized by pathologists. In order to further this work, we have now obtained FTIR spectra from stained (Papanicolau or Haematoxylin & Eosin) single cells using a benchtop spectrometer. This would be the logical step towards a clinical application in cancer diagnosis. The data here presented show that staining caused a decreased intensity of the peaks at 2920 cm?1 and 2850 cm?1, and the appearance of stronger peaks at 1374 cm?1 and 1040 cm?1. The clinical applications are discussed.	May 2010
B16-Test Beamline	Charge sharing in double-sided 3D Medipix2 detectors D. Pennicard , C. Fleta , R. Bates , V. O'shea , C. Parkes , G. Pellegrini , L. Lozano , J. Marchal , N. Tartoni Nuclear Instruments And Methods In Physics Research Section A 412-415 DOI: 10.1016/j.nima.2009.01.095 Show Abstract ▼ Abstract: 3D detectors are photodiode detectors with n- and p-type electrode columns passing through a silicon substrate. This structure gives a much smaller spacing between the electrodes than in a standard photodiode, greatly reducing the detector's operating voltage and collection time. The device structure also reduces charge sharing between adjacent pixels. This improves the image quality, making these detectors potentially useful for applications such as X-ray diffraction experiments in synchrotrons.A set of silicon detectors with a simplified "double-sided" 3D structure have been fabricated. After being bump-bonded to Medipix2 single-photon-counting readout chips, they have been tested using X-rays and alpha particles. The test results show that the 3D detectors have substantially lower charge sharing than a planar detector of the same thickness. (c) 2009 Elsevier B.V. All rights reserved.	Jun 2009

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