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Instruments / Technical Area	Publication Details	Published	Actions
B21-High Throughput SAXS	Ethosomes for coenzyme Q10 cutaneous administration: From design to 3D skin tissue evaluation Maddalena Sguizzato , Paolo Mariani , Francesco Spinozzi , Mascia Benedusi , Franco Cervellati , Rita Cortesi , Markus Drechsler , Roxane Prieux , Giuseppe Valacchi , Elisabetta Esposito Antioxidants 9 DOI: 10.3390/antiox9060485 Diamond Proposal Number(s): [21035] Open Access Show Abstract ▼ Abstract: Ethosome represents a smart transdermal vehicle suitable for solubilization and cutaneous application of drugs. Coenzyme Q10 is an endogenous antioxidant whose supplementation can counteract many cutaneous disorders and pathologies. In this respect, the present study describes the production, characterization, and cutaneous protection of phosphatidylcholine based ethosomes as percutaneous delivery systems for coenzyme Q10. CoQ10 entrapment capacity in ethosomes was almost 100%, vesicles showed the typical ‘fingerprint’ structure, while mean diameters were around 270 nm, undergoing an 8% increase after 3 months from production. An ex-vivo study, conducted by transmission electron microscopy, could detect the uptake of ethosomes in human skin fibroblasts and the passage of the vesicles through 3D reconstituted human epidermis. Immunofluorescence analyses were carried on both on fibroblasts and 3D reconstituted human epidermis treated with ethosomes in the presence of H2O2 as oxidative stress challenger, evaluating 4-hydroxynonenal protein adducts which is as a reliable biomarker for oxidative damage. Notably, the pretreatment with CoQ10 loaded in ethosomes exerted a consistent protective effect against oxidative stress, in both models, fibroblasts and in reconstituted human epidermis respectively.	Jun 2020

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B21-High Throughput SAXS

Ethosomes for coenzyme Q10 cutaneous administration: From design to 3D skin tissue evaluation

Maddalena Sguizzato , Paolo Mariani , Francesco Spinozzi , Mascia Benedusi , Franco Cervellati , Rita Cortesi , Markus Drechsler , Roxane Prieux , Giuseppe Valacchi , Elisabetta Esposito

Antioxidants 9

DOI: 10.3390/antiox9060485

Diamond Proposal Number(s): [21035]