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Instruments / Technical Area	Publication Details	Published	Actions
I14-Hard X-ray Nanoprobe	Incorporation of Tb and Gd improves the diagnostic functionality of magnetotactic bacteria Lucia Gandarias , Elizabeth M. Jefremovas , David Gandia , Lourdes Marcano , Virginia Martínez-Martínez , Pedro Ramos-Cabrer , Daniel M. Chevrier , Sergio Valencia , Luis Fernández Barquín , M. Luisa Fdez-Gubieda , Javier Alonso , Ana García-Prieto , Alicia Muela Materials Today Bio 2 DOI: 10.1016/j.mtbio.2023.100680 Diamond Proposal Number(s): [28868] Open Access Show Abstract ▼ Abstract: Magnetotactic bacteria are envisaged as potential theranostic agents. Their internal magnetic compass, chemical specificity and natural motility enable these microorganisms to behave as nanorobots, as they can be tracked and guided towards specific regions and activated to generate a therapeutic response. Here we provide additional diagnostic functionalities to magnetotactic bacteria Magnetospirillum gryphiswaldense MSR-1 while retaining their intrinsic capabilities. These additional functionalities are achieved by incorporating Tb or Gd to the bacteria by culturing them in Tb/Gd supplemented media. The incorporation of Tb provides luminescence properties, enabling potential applications of bacteria as biomarkers. The incorporation of Gd turns bacteria into dual contrast agents for magnetic resonance imaging, since Gd adds T1 contrast to the existing T2 contrast of unmodified bacteria. Given their potential clinical applications, the diagnostic ability of the modified MSR-1 has been successfully tested in vitro in two cell models, confirming their suitability as fluorescent markers (Tb-MSR-1) and dual contrast agents for MR1 (Gd-MSR-1).	May 2023
I22-Small angle scattering & Diffraction	Structuring supramolecular hyaluronan hydrogels via peptide self-assembly for modulating the cell microenvironment Yichen Yuan , Yejiao Shi , Jayati Banerjee , Amin Sadeghpour Dilmaghani , Helena S. Azevedo Materials Today Bio 12 DOI: 10.1016/j.mtbio.2023.100598 Diamond Proposal Number(s): [25037] Open Access Show Abstract ▼ Abstract: The use of synthetic extracellular matrices (ECMs) in fundamental in vitro cell culture studies has been instrumental for investigating the interplay between cells and matrix components. To provide cells with a more native environment in vitro, it is desirable to design matrices that are biomimetic and emulate compositional and structural features of natural ECMs. Here, the supramolecular fabrication of peptide-hyaluronan (HA) hydrogels is presented as promising ECM surrogates, combining HA and rationally designed cationic amphipatic peptides [(KI)nK, lysine (K), isoleucine (I), n = 2–6] whose mechanical properties and microstructure are tunable by the peptide sequence. (KI)nK peptides adopt β-sheet configuration and self-assemble into filamentous nanostructures triggered by pH or ionic strength. The self-assembly propensity of (KI)nK peptides increases with the sequence length, forming single phase hydrogels (shorter peptides) or with phase separation (longer peptides) in presence of the anionic polyelectrolyte HA through electrostatic complexations. The gel phase formed in (KI)nK-HA complexes exhibits viscoelastic behavior and triggers the formation of human mesenchymal stem cell (MSC) spheroids which disassemble over the time. It is anticipated that these (KI)nK-HA hydrogels with tunable physical and biochemical properties offer a promising platform for in vitro applications and in stem cell therapy.	Mar 2023

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