Diamond Publications - Search Results

Search Again...

These results include publications that have not yet been reviewed and processed by Diamond Light Source. To view only processed publications click here.

You can use the folder icon under Actions to collate papers as required. You can then click on View Folder in the left-hand navigation to review and/or download your folder.

One item found (0 items not approved).

Instruments / Technical Area	Publication Details	Published	Actions
B23-Circular Dichroism I22-Small angle scattering & Diffraction	Three-dimensional printable enzymatically active plastics William H. Zhang , Graham J. Day , Ioannis Zampetakis , Michele Carrabba , Zhongyang Zhang , Ben M. Carter , Norman Govan , Colin Jackson , Menglin Chen , Adam W. Perriman Acs Applied Polymer Materials DOI: 10.1021/acsapm.1c00845 Diamond Proposal Number(s): [17972, 18006] Open Access Show Abstract ▼ Abstract: Here, we describe a facile route to the synthesis of enzymatically active highly fabricable plastics, where the enzyme is an intrinsic component of the material. This is facilitated by the formation of an electrostatically stabilized enzyme–polymer surfactant nanoconstruct, which, after lyophilization and melting, affords stable macromolecular dispersions in a wide range of organic solvents. A selection of plastics can then be co-dissolved in the dispersions, which provides a route to bespoke 3D enzyme plastic nanocomposite structures using a wide range of fabrication techniques, including melt electrowriting, casting, and piston-driven 3D printing. The resulting constructs comprising active phosphotriesterase (arPTE) readily detoxify organophosphates with persistent activity over repeated cycles and for long time periods. Moreover, we show that the protein guest molecules, such as arPTE or sfGFP, increase the compressive Young’s modulus of the plastics and that the identity of the biomolecule influences the nanomorphology and mechanical properties of the resulting materials. Overall, we demonstrate that these biologically active nanocomposite plastics are compatible with state-of-the-art 3D fabrication techniques and that the methodology could be readily applied to produce robust and on-demand smart nanomaterial structures.	Nov 2021

Instruments / Technical Area

Publication Details

Published

Actions

B23-Circular Dichroism
I22-Small angle scattering & Diffraction

Three-dimensional printable enzymatically active plastics

William H. Zhang , Graham J. Day , Ioannis Zampetakis , Michele Carrabba , Zhongyang Zhang , Ben M. Carter , Norman Govan , Colin Jackson , Menglin Chen , Adam W. Perriman

Acs Applied Polymer Materials

DOI: 10.1021/acsapm.1c00845

Diamond Proposal Number(s): [17972, 18006]