Search Results

You searched for all publications:

with publication states 'Published' 'Published (Approved)'

Search Again...

These results include publications that have not yet been reviewed and processed by Diamond Light Source. To view only processed publications click here.

You can use the folder icon under Actions to collate papers as required. You can then click on View Folder in the left-hand navigation to review and/or download your folder.

Exact matches
Related results

2 items found (0 items not approved), displaying all items.1

Instruments / Technical Area	Publication Details	Published	Actions
B23-Circular Dichroism	Heparin derivatives for the targeting of multiple activities in the inflammatory response Noemi Veraldi , Ashley J. Hughes , Timothy R. Rudd , Huw B. Thomas , Steven W. Edwards , Lynsay Hadfield , Mark A. Skidmore , Giuliano Siligardi , Cesare Cosentino , Janis K. Shute , Annamaria Naggi , Edwin A. Yates Carbohydrate Polymers 117, 400 - 407 DOI: 10.1016/j.carbpol.2014.09.079 PMID: 25498652 Diamond Proposal Number(s): [8027] Show Abstract ▼ Abstract: An attractive strategy for ameliorating symptoms arising from the multi-faceted processes of excessive and/or continual inflammation would be to identify compounds able to interfere with multiple effectors of inflammation. The well-tolerated pharmaceutical, heparin, is capable of acting through several proteins in the inflammatory cascade, but its use is prevented by strong anticoagulant activity. Derivatives of heparin involving the periodate cleavage of 2,3 vicinal diols in non-sulfated uronate residues (glycol- split) and replacement of N-sulphamido- with N-acetamido- groups in glucosamine residues, capable of inhibiting neutrophil elastase activity in vitro, while exhibiting attenuated anticoagulant properties, have been identified and characterised. These also interact with two other important modulators of the inflammatory response, IL-8 and TNF-alpha. It is therefore feasible in principle to modulate several activities, while minimising anticoagulant side effects, providing a platform from which improved anti- inflammatory agents might be developed.	Oct 2014
B23-Circular Dichroism	Antithrombin stabilisation by sulfated carbohydrates correlates with anticoagulant activity Marcelo Andrade De Lima , Ashley Hughes , Noemi Veraldi , Timothy Rudd , Rohanah Hussain , Adriana Brito , Suely Chavante , Ivarne Tersariol , Giuliano Siligardi , Helena B. Nader , Edwin Yates Medchemcomm DOI: 10.1039/c3md00048f Show Abstract ▼ Abstract: Thermal stabilisation of native antithrombin-III (AT), determined using differential scanning fluorimetry, correlated with the anticoagulant activity of heparin and heparin-related saccharides. Similar conformational changes were induced in native AT by a variety of active and inactive heparin-related sulfated carbohydrates, measured in solution using synchrotron radiation circular dichroism, and their anticoagulant activities. Measurement of native AT stabilisation provides a convenient assay for prospective anticoagulants and represents an additional parameter by which to compare biosimilar heparins.	Apr 2013

Publications Database

Search Results

You searched for all publications:

Search Again...

Subject Areas (check all that apply) select all

Instruments used to collect data (check all that apply) select all

Collaborations involved (check all that apply) select all

Diamond Offline Facilities used

Relevant Technical Areas (check all that apply) select all

Menu for Anonymous User