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Instruments / Technical Area	Publication Details	Published	Actions
I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography	A supramolecular assembly mediates lentiviral DNA integration Allison Ballandras-Colas , Daniel P. Maskell , Erik Serrao , Julia Locke , Paolo Swuec , Stefán R. Jónsson , Abhay Kotecha , Nicola J. Cook , Valerie E. Pye , Ian A. Taylor , Valgerdur Andrésdóttir , Alan N. Engelman , Alessandro Costa , Peter Cherepanov Science 355, 93 - 95 DOI: 10.1126/science.aah7002 Diamond Proposal Number(s): [13775] Show Abstract ▼ Abstract: Retroviral integrase (IN) functions within the intasome nucleoprotein complex to catalyze insertion of viral DNA into cellular chromatin. Using cryo–electron microscopy, we now visualize the functional maedi-visna lentivirus intasome at 4.9 angstrom resolution. The intasome comprises a homo-hexadecamer of IN with a tetramer-of-tetramers architecture featuring eight structurally distinct types of IN protomers supporting two catalytically competent subunits. The conserved intasomal core, previously observed in simpler retroviral systems, is formed between two IN tetramers, with a pair of C-terminal domains from flanking tetramers completing the synaptic interface. Our results explain how HIV-1 IN, which self-associates into higher-order multimers, can form a functional intasome, reconcile the bulk of early HIV-1 IN biochemical and structural data, and provide a lentiviral platform for design of HIV-1 IN inhibitors.	Jan 2017

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