Search Results

You searched for all publications:

with publication states 'Published (Approved)'

Search Again...

These results only include publications that have been reviewed and processed by Diamond Light Source. To also view papers that have not yet been processed click here.

You can use the folder icon under Actions to collate papers as required. You can then click on View Folder in the left-hand navigation to review and/or download your folder.

Exact matches
Related results

12,023 items found (0 items not approved), displaying 41 to 50.[First/Prev] 1, 2, 3, 4, 5, 6, 7, 8 [Next/Last]

Instruments / Technical Area	Publication Details	Published
I11-High Resolution Powder Diffraction	Early age hydration and application of blended magnesium potassium phosphate cements for reduced corrosion of reactive metals Laura J. Gardner , Claire L. Corkhill , Sam A. Walling , James E. Vigor , Claire A. Murray , Chiu C. Tang , John L. Provis , Neil C. Hyatt Cement And Concrete Research 143 DOI: 10.1016/j.cemconres.2021.106375 Diamond Proposal Number(s): [10038] Open Access Show Abstract ▼ Abstract: Magnesium potassium phosphate cements (MKPC) were investigated to determine their efficacy towards retardation of reactive uranium metal corrosion. Optimised low-water content, fly ash (FA) and blast furnace slag (BFS) blended MKPC formulations were developed and their fluidity, hydration behaviour, strength and phase assemblage investigated. In-situ time resolved synchrotron powder X-ray diffraction was used to detail the early age (~60 h) phase assemblage development and hydration kinetics, where the inclusion of BFS was observed to delay the formation of struvite-K by ~14 h compared to FA addition (~2 h). All samples set within this period, suggesting the possible formation of a poorly crystalline binding phase prior to struvite-K crystallisation. Long-term corrosion trials using metallic uranium indicated that MKPC systems are capable of limiting uranium corrosion rates (reduced by half), when compared to a UK nuclear industry grout, which highlights their potential application radioactive waste immobilisation.	May 2021
I03-Macromolecular Crystallography	Inhibition of Plasmodium falciparum Lysyl‐tRNA synthetase via a piperidine‐ring scaffold inspired Cladosporin analogues Palak Babbar , Mizuki Sato , Yogavel Manickam , Siddhartha Mishra , Karl Harlos , Swati Gupta , Suhel Parvez , Haruhisa Kikuchi , Amit Sharma Chembiochem DOI: 10.1002/cbic.202100212 Diamond Proposal Number(s): [19946] Show Abstract ▼ Abstract: Plasmodium falciparum lysyl tRNA synthetase ( Pf KRS) represent a promising therapeutic anti‐malarial target. Cladosporin, a tool compound was identified as a selective and potent PfKRS inhibitor but lacks metabolic stability. Here, we report chemical synthesis, biological evaluation and structural characterization of analogues where the tetrahydropyran (THP) frame of cladosporin is replaced with the piperidine ring bearing functional group variations. Thermal binding, enzymatic, kinetic and parasitic assays complemented with x‐ray crystallography reveals compounds to be of moderate potency. Co‐crystals of Cla‐B and Cla‐C with PfKRS reveals key atomic configurations that allow drug binding to, and inhibition of the enzyme. Collectively, these piperidine ring scaffold inhibitors lays a framework for further structural editing and functional modifications of cladosporin scaffold to obtain a potent lead.	May 2021
I09-Surface and Interface Structural Analysis	Conformational control of chemical reactivity for surface‐confined Ru‐porphyrins Peter Knecht , Joachim Reichert , Peter S. Deimel , Peter Feulner , Felix Haag , Francesco Allegretti , Manuela Garnica , Martin Schwarz , Willi Auwärter , Paul T. P. Ryan , Tien-Lin Lee , David A. Duncan , Ari Paavo Seitsonen , Johannes V. Barth , Anthoula Chrysa Papageorgiou Angewandte Chemie International Edition DOI: 10.1002/anie.202104075 Diamond Proposal Number(s): [24320] Open Access Show Abstract ▼ Abstract: We assess the crucial role of tetrapyrrole flexibility in the CO ligation to distinct Ru‐porphyrins supported on an atomistically well‐defined Ag(111) substrate. Our systematic real space visualisation and manipulation experiments with scanning tunnelling microscopy directly probe the ligation, while bond‐resolving atomic force microscopy and X‐ray standing waves measurements characterise the geometry, X‐ray and ultraviolet photoelectron spectroscopy the electronic structure, and temperature programmed desorption the binding strength. Density functional theory calculations provide additional insight into the functional interface. We unambiguously demonstrate that the substituents regulate the interfacial conformational adaptability, either promoting or obstructing the uptake of axial CO adducts.	May 2021
I22-Small angle scattering & Diffraction	I22: SAXS/WAXS beamline at Diamond Light Source – an overview of 10 years operation Andrew Smith , S. G. Alcock , L. S. Davidson , J. H. Emmins , J. C. Hiller Bardsley , P. Holloway , M. Malfois , A. R. Marshall , C. L. Pizzey , S. E. Rogers , O. Shebanova , T. Snow , J. P. Sutter , E. P. Williams , N. J. Terrill Journal Of Synchrotron Radiation 28 DOI: 10.1107/S1600577521002113 Open Access Show Abstract ▼ Abstract: Beamline I22 at Diamond Light Source is dedicated to the study of soft-matter systems from both biological and materials science. The beamline can operate in the range 3.7 keV to 22 keV for transmission SAXS and 14 keV to 20 keV for microfocus SAXS with beam sizes of 240 µm × 60 µm [full width half-maximum (FWHM) horizontal (H) × vertical (V)] at the sample for the main beamline, and approximately 10 µm × 10 µm for the dedicated microfocusing platform. There is a versatile sample platform for accommodating a range of facilities and user-developed sample environments. The high brilliance of the insertion device source on I22 allows structural investigation of materials under extreme environments (for example, fluid flow at high pressures and temperatures). I22 provides reliable access to millisecond data acquisition timescales, essential to understanding kinetic processes such as protein folding or structural evolution in polymers and colloids.	May 2021
I22-Small angle scattering & Diffraction	Extending synchrotron SAXS instrument ranges through addition of a portable, inexpensive USAXS module with vertical rotation axes Brian R. Pauw , Andrew Smith , Tim Snow , Olga Shebanova , John P. Sutter , Jan Ilavsky , Daniel Hermida-Merino , Glen J. Smales , Nicholas J. Terrill , Andreas F. Thünemann , Wim Bras Journal Of Synchrotron Radiation 28 DOI: 10.1107/S1600577521003313 Open Access Show Abstract ▼ Abstract: Ultra-SAXS can enhance the capabilities of existing synchrotron SAXS/WAXS beamlines. A compact ultra-SAXS module has been developed, which extends the measurable q-range with 0.0015 ≤ q (nm−1) ≤ 0.2, allowing structural dimensions in the range 30 ≤ D (nm) ≤ 4000 to be probed in addition to the range covered by a high-end SAXS/WAXS instrument. By shifting the module components in and out on their respective motor stages, SAXS/WAXS measurements can be easily and rapidly interleaved with USAXS measurements. The use of vertical crystal rotation axes (horizontal diffraction) greatly simplifies the construction, at minimal cost to efficiency. In this paper, the design considerations, realization and synchrotron findings are presented. Measurements of silica spheres, an alumina membrane, and a porous carbon catalyst are provided as application examples.	May 2021
I14-Hard X-ray Nanoprobe	The Hard X-ray Nanoprobe beamline at Diamond Light Source Paul D. Quinn , Lucia Alianelli , Miguel Gomez-Gonzalez , David Mahoney , Fernando Cacho-Nerin , Andrew Peach , Julia E. Parker Journal Of Synchrotron Radiation 28 DOI: 10.1107/S1600577521002502 Open Access Show Abstract ▼ Abstract: The Hard X-ray Nanoprobe beamline, I14, at Diamond Light Source is a new facility for nanoscale microscopy. The beamline was designed with an emphasis on multi-modal analysis, providing elemental mapping, speciation mapping by XANES, structural phase mapping using nano-XRD and imaging through differential phase contrast and ptychography. The 185 m-long beamline operates over a 5 keV to 23 keV energy range providing a ≤50 nm beam size for routine user experiments and a flexible scanning system allowing fast acquisition. The beamline achieves robust and stable operation by imaging the source in the vertical direction and implementing horizontally deflecting primary optics and an overfilled secondary source in the horizontal direction. This paper describes the design considerations, optical layout, aspects of the hardware engineering and scanning system in operation as well as some examples illustrating the beamline performance.	May 2021
I23-Long wavelength MX	X-ray tomographic reconstruction and segmentation pipeline for the long-wavelength macromolecular crystallography beamline at Diamond Light Source Daniil Kazantsev , Ramona Duman , Armin Wagner , Vitaliy Mykhaylyk , Kazimir Wanelik , Mark Basham , Nicola Wadeson Journal Of Synchrotron Radiation 28 DOI: 10.1107/S1600577521003453 Open Access Show Abstract ▼ Abstract: In this paper a practical solution for the reconstruction and segmentation of low-contrast X-ray tomographic data of protein crystals from the long-wavelength macromolecular crystallography beamline I23 at Diamond Light Source is provided. The resulting segmented data will provide the path lengths through both diffracting and non-diffracting materials as basis for analytical absorption corrections for X-ray diffraction data taken in the same sample environment ahead of the tomography experiment. X-ray tomography data from protein crystals can be difficult to analyse due to very low or absent contrast between the different materials: the crystal, the sample holder and the surrounding mother liquor. The proposed data processing pipeline consists of two major sequential operations: model-based iterative reconstruction to improve contrast and minimize the influence of noise and artefacts, followed by segmentation. The segmentation aims to partition the reconstructed data into four phases: the crystal, mother liquor, loop and vacuum. In this study three different semi-automated segmentation methods are experimented with by using Gaussian mixture models, geodesic distance thresholding and a novel morphological method, RegionGrow, implemented specifically for the task. The complete reconstruction-segmentation pipeline is integrated into the MPI-based data analysis and reconstruction framework Savu, which is used to reduce computation time through parallelization across a computing cluster and makes the developed methods easily accessible.	May 2021
I10-Beamline for Advanced Dichroism	Room-temperature intrinsic ferromagnetism in epitaxial CrTe2 ultrathin films Xiaoqian Zhang , Qiangsheng Lu , Wenqing Liu , Wei Niu , Jiabao Sun , Jacob Cook , Mitchel Vaninger , Paul F. Miceli , David J. Singh , Shang-Wei Lian , Tay-Rong Chang , Xiaoqing He , Jun Du , Liang He , Rong Zhang , Guang Bian , Yongbing Xu Nature Communications 12 DOI: 10.1038/s41467-021-22777-x Diamond Proposal Number(s): [22532] Open Access Show Abstract ▼ Abstract: While the discovery of two-dimensional (2D) magnets opens the door for fundamental physics and next-generation spintronics, it is technically challenging to achieve the room-temperature ferromagnetic (FM) order in a way compatible with potential device applications. Here, we report the growth and properties of single- and few-layer CrTe2, a van der Waals (vdW) material, on bilayer graphene by molecular beam epitaxy (MBE). Intrinsic ferromagnetism with a Curie temperature (TC) up to 300 K, an atomic magnetic moment of ~0.21 𝜇B μ B /Cr and perpendicular magnetic anisotropy (PMA) constant (Ku) of 4.89 × 105 erg/cm3 at room temperature in these few-monolayer films have been unambiguously evidenced by superconducting quantum interference device and X-ray magnetic circular dichroism. This intrinsic ferromagnetism has also been identified by the splitting of majority and minority band dispersions with ~0.2 eV at Г point using angle-resolved photoemission spectroscopy. The FM order is preserved with the film thickness down to a monolayer (TC ~ 200 K), benefiting from the strong PMA and weak interlayer coupling. The successful MBE growth of 2D FM CrTe2 films with room-temperature ferromagnetism opens a new avenue for developing large-scale 2D magnet-based spintronics devices.	May 2021
I22-Small angle scattering & Diffraction	Tomographic X-ray scattering based on invariant reconstruction: analysis of the 3D nanostructure of bovine bone Paolino De Falco , Richard Weinkamer , Wolfgang Wagermaier , Chenghao Li , Tim Snow , Nicholas J. Terrill , Himadri Gupta , Pawan Goyal , Martin Stoll , Peter Benner , Peter Fratzl Journal Of Applied Crystallography 54 DOI: 10.1107/S1600576721000881 Diamond Proposal Number(s): [18524] Open Access Show Abstract ▼ Abstract: Small-angle X-ray scattering (SAXS) is an effective characterization technique for multi-phase nanocomposites. The structural complexity and heterogeneity of biological materials require the development of new techniques for the 3D characterization of their hierarchical structures. Emerging SAXS tomographic methods allow reconstruction of the 3D scattering pattern in each voxel but are costly in terms of synchrotron measurement time and computer time. To address this problem, an approach has been developed based on the reconstruction of SAXS invariants to allow for fast 3D characterization of nanostructured inhomogeneous materials. SAXS invariants are scalars replacing the 3D scattering patterns in each voxel, thus simplifying the 6D reconstruction problem to several 3D ones. Standard procedures for tomographic reconstruction can be directly adapted for this problem. The procedure is demonstrated by determining the distribution of the nanometric bone mineral particle thickness (T parameter) throughout a macroscopic 3D volume of bovine cortical bone. The T parameter maps display spatial patterns of particle thickness in fibrolamellar bone units. Spatial correlation between the mineral nanostructure and microscopic features reveals that the mineral particles are particularly thin in the vicinity of vascular channels.	Apr 2021
	Cytoplasmic CPSF6 regulates HIV-1 capsid trafficking and infection in a cyclophilin A-dependent manner Zhou Zhong , Jiying Ning , Emerson A. Boggs , Sooin Jang , Callen Wallace , Cheryl Telmer , Marcel P. Bruchez , Jinwoo Ahn , Alan N. Engelman , Peijun Zhang , Simon C. Watkins , Zandrea Ambrose Mbio 12 DOI: 10.1128/mBio.03142-20 Open Access Show Abstract ▼ Abstract: Human immunodeficiency virus type 1 (HIV-1) capsid binds host proteins during infection, including cleavage and polyadenylation specificity factor 6 (CPSF6) and cyclophilin A (CypA). We observe that HIV-1 infection induces higher-order CPSF6 formation, and capsid-CPSF6 complexes cotraffic on microtubules. CPSF6-capsid complex trafficking is impacted by capsid alterations that reduce CPSF6 binding or by excess cytoplasmic CPSF6 expression, both of which are associated with decreased HIV-1 infection. Higher-order CPSF6 complexes bind and disrupt HIV-1 capsid assemblies in vitro. Disruption of HIV-1 capsid binding to CypA leads to increased CPSF6 binding and altered capsid trafficking, resulting in reduced infectivity. Our data reveal an interplay between CPSF6 and CypA that is important for cytoplasmic capsid trafficking and HIV-1 infection. We propose that CypA prevents HIV-1 capsid from prematurely engaging cytoplasmic CPSF6 and that differences in CypA cellular localization and innate immunity may explain variations in HIV-1 capsid trafficking and uncoating in CD4+ T cells and macrophages.	Apr 2021

Publications Database

Search Results

You searched for all publications:

Search Again...

Subject Areas (check all that apply) select all

Instruments used to collect data (check all that apply) select all

Collaborations involved (check all that apply) select all

Diamond Offline Facilities used

Relevant Technical Areas (check all that apply) select all

Menu for Anonymous User