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Instruments / Technical Area	Publication Details	Published	Actions
I13-2-Diamond Manchester Imaging	Time-resolved in situ synchrotron-microCT: 4D deformation of bone and bone analogues using digital volume correlation Marta Pena Fernandez , Alexander P. Kao , Roxane Bonithon , David Howells , Andrew J. Bodey , Kazimir Wanelik , Frank Witte , Richard Johnston , Hari Arora , Gianluca Tozzi Acta Biomaterialia 20 DOI: 10.1016/j.actbio.2021.06.014 Diamond Proposal Number(s): [22575, 20132] Show Abstract ▼ Abstract: Digital volume correlation (DVC) in combination with high-resolution micro-computed tomography (microCT) imaging and in situ mechanical testing is gaining popularity for quantifying 3D full-field strains in bone and biomaterials. However, traditional in situ time-lapsed (i.e., interrupted) mechanical testing cannot fully capture the dynamic strain mechanisms in viscoelastic biological materials. The aim of this study was to investigate the time-resolved deformation of bone structures and analogues via continuous in situ synchrotron-radiation microCT (SR-microCT) compression and DVC to gain a better insight into their structure-function relationships. Fast SR-microCT imaging enabled the deformation behaviour to be captured with high temporal and spatial resolution. Time-resolved DVC highlighted the relationship between local strains and damage initiation and progression in the different biostructures undergoing plastic deformation, bending and/or buckling of their main microstructural elements. The results showed that SR-microCT continuous mechanical testing complemented and enhanced the information obtained from time-lapsed testing, which may underestimate the 3D strain magnitudes as a result of the stress relaxation occurring in between steps before image acquisition in porous biomaterials. Altogether, the findings of this study highlight the importance of time-resolved in situ experiments to fully characterise the time-dependent mechanical behaviour of biological tissues and biomaterials and to further explore their micromechanics under physiologically relevant conditions.	Jun 2021

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I13-2-Diamond Manchester Imaging

Time-resolved in situ synchrotron-microCT: 4D deformation of bone and bone analogues using digital volume correlation

Marta Pena Fernandez , Alexander P. Kao , Roxane Bonithon , David Howells , Andrew J. Bodey , Kazimir Wanelik , Frank Witte , Richard Johnston , Hari Arora , Gianluca Tozzi

Acta Biomaterialia 20

DOI: 10.1016/j.actbio.2021.06.014

Diamond Proposal Number(s): [22575, 20132]

Show Abstract ▼

Jun 2021