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Instruments / Technical Area	Publication Details	Published	Actions
I03-Macromolecular Crystallography I04-Macromolecular Crystallography	Modular design of self-assembling peptide-based nanotubes Natasha Burgess , Thomas H. Sharp , Franziska Thomas , Christopher W. Wood , Andrew Thomson , Nathan Zaccai , Leo Brady , Louise Serpell , Derek N. Woolfson Journal Of The American Chemical Society 137 (33) DOI: 10.1021/jacs.5b03973 Diamond Proposal Number(s): [8922] Show Abstract ▼ Abstract: An ability to design peptide-based nanotubes (PNTs) rationally with defined and mutable internal channels would advance understanding of peptide self-assembly, and present new biomaterials for nanotechnology and medicine. PNTs have been made from Fmoc dipeptides, cyclic peptides, and lock-washer helical bundles. Here we show that blunt-ended α-helical barrels, that is, preassembled bundles of α-helices with central channels, can be used as building blocks for PNTs. This approach is general and systematic, and uses a set of de novo helical bundles as standards. One of these bundles, a hexameric α-helical barrel, assembles into highly ordered PNTs, for which we have determined a structure by combining cryo-transmission electron microscopy, X-ray fiber diffraction, and model building. The structure reveals that the overall symmetry of the peptide module plays a critical role in ripening and ordering of the supramolecular assembly. PNTs based on pentameric, hexameric, and heptameric α-helical barrels sequester hydrophobic dye within their lumens.	Aug 2015

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I03-Macromolecular Crystallography
I04-Macromolecular Crystallography

Modular design of self-assembling peptide-based nanotubes

Natasha Burgess , Thomas H. Sharp , Franziska Thomas , Christopher W. Wood , Andrew Thomson , Nathan Zaccai , Leo Brady , Louise Serpell , Derek N. Woolfson

Journal Of The American Chemical Society 137 (33)

DOI: 10.1021/jacs.5b03973

Diamond Proposal Number(s): [8922]

Show Abstract ▼

Aug 2015