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Instruments / Technical Area	Publication Details	Published	Actions
I22-Small angle scattering & Diffraction	Structure and Stability of PEG- and Mixed PEG-Layer-Coated Nanoparticles at High Particle Concentrations Studied In Situ by Small-Angle X-Ray Scattering Florian Schulz , Johannes Möller , Felix Lehmkühler , Andrew J. Smith , Tobias Vossmeyer , Holger Lange , Gerhard Grübel , Martin A. Schroer Particle & Particle Systems Characterization 116 DOI: 10.1002/ppsc.201700319 Diamond Proposal Number(s): [11192, 16193] Show Abstract ▼ Abstract: Ligand-layer structure and stability of gold nanoparticles (AuNP) coated with α-methoxypoly(ethylene glycol)-ω-(11-mercaptoundecanoate) (PEGMUA) layers and mixed layers of PEGMUA and 11-mercaptoundecanoic acid (MUA) at high AuNP concentrations are studied in situ by small-angle X-ray scattering (SAXS). The thickness of the ligand layer is modified by the molecular weight of the PEG-ligands (2 and 5 kDa), and the PEG-grafting density is decreased by coadsorption of MUA. The response of the conjugates to a pressure of up to 4 kbar is probed. The results indicate strongly hydrated PEG layers at high grafting densities. The stability of the mixed ligand-layer conjugates is lower. This is most probably due to enhanced interparticle PEG–PEG interactions at lower grafting densities. The presented study demonstrates that a detailed structural characterization of polymer ligand layers in situ and in response to external stimuli is possible with SAXS.	Dec 2017
I14-Hard X-ray Nanoprobe	Nuclear uptake of gold nanoparticles deduced using dual‐angle X‐ray fluorescence mapping Aaron Mcculloch , Lindsey Bennie , Jonathan A. Coulter , Helen O. Mccarthy , Brendan Dromey , David R. Grimes , Paul Quinn , Balder Villagomez-bernabe , Frederick Currell Particle & Particle Systems Characterization 6 DOI: 10.1002/ppsc.201900140 Diamond Proposal Number(s): [16931, 17932] Show Abstract ▼ Abstract: Studies into the cell nucleus' incorporation of gold nanoparticles (AuNPs) are often limited by ambiguities arising from conventional imaging techniques. Indeed, it is suggested that to date there is no unambiguous imaging evidence for such uptake in whole cells, particularly at the single nanoparticle level. This shortcoming in understanding exists despite the nucleus being the most important subcellular compartment in eukaryotes and gold being the most commonly used metal nanoparticle in medical applications. Here, dual‐angle X‐ray flouresence is used to show individually resolved nanoparticles within the cell nucleus, finding them to be well separated and 79% of the intranuclear population to be monodispersed. These findings have important implications for nanomedicine, illustrated here through a specific exemplar of the predicted enhancement of radiation effects arising from the observed AuNPs, finding intranuclear dose enhancements spanning nearly five orders of magnitude.	Jul 2019

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