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Instruments / Technical Area	Publication Details	Published	Actions
I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography	Complex pectin metabolism by gut bacteria reveals novel catalytic functions Didier Ndeh , Artur Rogowski , Alan Cartmell , Ana S. Luis , Arnaud Basle , Joseph Gray , Immacolata Venditto , Jonathon Briggs , Xiaoyang Zhang , Aurore Labourel , Nicolas Terrapon , Fanny Buffetto , Sergey Nepogodiev , Yao Xiao , Robert A. Field , Yanping Zhu , Malcolm A. O’neill , Breeanna R. Urbanowicz , William S. York , Gideon J. Davies , D. Wade Abbott , Marie-Christine Ralet , Eric C. Martens , Bernard Henrissat , Harry J. Gilbert Nature 411 DOI: 10.1038/nature21725 Diamond Proposal Number(s): [1960, 7854, 9948] Show Abstract ▼ Abstract: The metabolism of carbohydrate polymers drives microbial diversity in the human gut microbiota. It is unclear, however, whether bacterial consortia or single organisms are required to depolymerize highly complex glycans. Here we show that the gut bacterium Bacteroides thetaiotaomicron uses the most structurally complex glycan known: the plant pectic polysaccharide rhamnogalacturonan-II, cleaving all but 1 of its 21 distinct glycosidic linkages. The deconstruction of rhamnogalacturonan-II side chains and backbone are coordinated to overcome steric constraints, and the degradation involves previously undiscovered enzyme families and catalytic activities. The degradation system informs revision of the current structural model of rhamnogalacturonan-II and highlights how individual gut bacteria orchestrate manifold enzymes to metabolize the most challenging glycan in the human diet.	Mar 2017

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