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Instruments / Technical Area	Publication Details	Published	Actions
I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography	Discovery and optimisation of wt-RET/KDR-selective inhibitors of RET V804M kinase Rebecca Newton , Bohdan Waszkowycz , Chitra Seewooruthun , Daniel Burschowsky , Mark Richards , Samantha Hitchin , Habiba Begum , Amanda Watson , Eleanor French , Niall Hamilton , Stuart Jones , Li-Ying Lin , Ian Waddell , Aude Echalier , Richard Bayliss , Allan M. Jordan , Donald Ogilvie Acs Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00615 Diamond Proposal Number(s): [8997] Open Access Show Abstract ▼ Abstract: A combination of focussed library and virtual screening, hit expansion and rational design has resulted in the development of a series of inhibitors of RETV804M kinase, the anticipated drug-resistant mutant of RET kinase. These agents do not inhibit the wild-type isoforms of RET or KDR and therefore offer a potential adjunct to RET inhibitors currently undergoing clinical evaluation.	Feb 2020

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