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High-speed crystal detection and characterization using a fast-readout detector

DOI: 10.1107/S0907444910028192 DOI Help
PMID: 20823554 PMID Help

Authors: Jun Aishima (Diamond Light Source) , Robin Owen (Diamond Light Source) , Emma Shepherd (Diamond Light Source) , Graeme Winter (Diamond Light Source) , Karl Levik (Diamond Light Source) , Paul Gibbons (Diamond Light Source) , Alun Ashton (Diamond Light Source) , Gwyndaf Evans (Diamond Light Source) , Danny Axford (Diamond Light Source)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Acta Crystallographica Section D Biological Crystallography , VOL 66 (9) , PAGES 1032-1035

State: Published (Approved)
Published: September 2010

Abstract: A novel raster-scanning method combining continuous sample translation with the fast readout of a Pilatus P6M detector has been developed on microfocus beamline I24 at Diamond Light Source. This fast grid-scan tool allows the rapid evaluation of large sample volumes without the need to increase the beam size at the sample through changes in beamline hardware. A slow version is available for slow-readout detectors. Examples of grid-scan use in centring optically invisible samples and in detecting and characterizing numerous microcrystals on a mesh-like holder illustrate the most common applications of the grid scan now in routine use on I24.

Journal Keywords: Macromolecular Crystallography; Microfocus; Grid Scan; Sample Characterization

Subject Areas: Biology and Bio-materials, Technique Development


Instruments: I24-Microfocus Macromolecular Crystallography