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Cystine-based MBioF for maintaining the antioxidant-oxidant balance in airways diseases

DOI: 10.1021/acsmedchemlett.8b00468 DOI Help

Authors: Marek Wiśniewski (Nicolaus Copernicus University in Toruń) , Adam Bieniek (Nicolaus Copernicus University in Toruń) , Katarzyna Roszek (Nicolaus Copernicus University in Toruń) , Joanna Czarnecka (Nicolaus Copernicus University in Toruń) , Paulina Bolibok (Nicolaus Copernicus University in Toruń) , Pilar Ferrer (Diamond Light Source) , Ivan Da Silva (ISIS Neutron and Muon Source) , Artur Piotr Terzyk (Nicolaus Copernicus University in Toruń)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Acs Medicinal Chemistry Letters

State: Published (Approved)
Published: November 2018

Abstract: Reactive oxygen species, contributing to oxidant-antioxidant imbalance, initiate damage to the airways cells, inflammatory processes and further pathophysiological effects. Enhancing anti-oxidant properties is the main prophylactic and therapeutic challenge. In this work, a newly synthesized and biocompatible structure of the metal-biomolecule frameworks (MBioF) harnessing cystine as a linker and magnesium as metal nodes, is presented. This structure provides crucial sulfhydryl groups of cysteine, with antioxidant activity, released stepwise in the site of delivery. We prove that once released, the compounds of MBioF increase the intracellular level of cysteine and total antioxidative capability of airways cells. Presented MBioF structures offer new perspectives for clinical applications as therapeutics or preventives maintaining the antioxidant-oxidant balance.

Journal Keywords: airways diseases; metal organic framework; MBioF; stepwise release; drug delivery system; cystine

Subject Areas: Biology and Bio-materials, Medicine


Technical Areas: