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High-Pressure Studies of Pharmaceuticals: An Exploration of the Behavior of Piracetam
Authors:
Francesca P. A.
Fabbiani
(School of Chemistry and Centre for Science at Extreme Conditions, The University of Edinburgh, U.K.)
,
Dave
Allan
(Diamond Light Source)
,
William I. F.
David
(Rutherford Appleton Laboratory, Didcot, U.K.)
,
Alistair J.
Davidson
(School of Chemistry and Centre for Science at Extreme Conditions, The University of Edinburgh, U.K.)
,
Alistair
Lennie
(Diamond Light Source)
,
Simon
Parsons
(School of Chemistry and Centre for Science at Extreme Conditions, The University of Edinburgh, U.K.)
,
Colin
Pulham
(University of Edinburgh)
,
John
Warren
(University of Liverpool)
Co-authored by industrial partner:
No
Type:
Journal Paper
Journal:
Crystal Growth & Design
, VOL 7 (6)
, PAGES 1115 - 1124
State:
Published (Approved)
Published:
May 2007
Abstract: The structural response of the nootropic drug piracetam (2-oxo-pyrrolidineacetamide) to both direct compression and high-pressure recrystallization from aqueous solution is reported. Crystals obtained by these methods have been characterized in situ by single-crystal X-ray diffraction. Compression of form II between pressures of 0.45-0.70 GPa caused a reversible, single- crystal to single-crystal transition to give a new polymorph, form V. Crystallization from a dilute aqueous solution of piracetam at a pressure of 0.6 GPa via crystallization of high-pressure ice-VI resulted in the formation of a previously unreported dihydrate. The molecular packing arrangements of these new structures are compared with the known polymorphs and hydrates of piracetam. This study highlights how the systematic variation of pressure is a powerful method for the exploration of polymorphism and solvate formation and has the potential to add a further dimension to polymorph screening of pharmaceuticals.
Subject Areas:
Chemistry,
Medicine
Facility: SRS Daresbury
Added On:
16/08/2010 12:21
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