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New strategy of controlled, stepwise release from novel MBioF and its potential application for drug delivery systems

DOI: 10.1007/s10450-018-00002-4 DOI Help

Authors: Adam Bieniek (Nicolaus Copernicus University in Toruń) , Marek Wiśniewski (Nicolaus Copernicus University in Toruń) , Katarzyna Roszek (Nicolaus Copernicus University in Toruń) , Paulina Bolibok (Nicolaus Copernicus University in Toruń) , Artur P. Terzyk (Nicolaus Copernicus University in Toruń) , Pilar Ferrer (Diamond Light Source) , Ivan Da Silva (ISIS Neutron and Muon Source)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Adsorption , VOL 29

State: Published (Approved)
Published: February 2019

Open Access Open Access

Abstract: Metal organic structures have gained recently an interest in many fields. Among them, metal–biomolecule framework materials with amino acids applied as organic linkers have attracted the growing attention. An application of tailored metal–biomolecule frameworks, easily decomposing in an acidic and/or reductive environment in a steerable way, is reported here. From these biocompatible, non-porous, and nanostructured drug carrier systems, the desirable portion of drug could be released depending on the portion of acid, i.e. immediately and/or in a multi-step process due to a structure decomposition. The application of naturally occurring elements as cystine ensures full biocompatibility of the obtained system as well as its degradation products. Presented materials offer potential application in drug delivery systems.

Journal Keywords: Metal organic framework; MBioF; Stepwise release; Drug delivery system; Cystine; Cysteine; Sorafenib

Subject Areas: Materials, Medicine

Technical Areas: