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Elemental imaging of trace elements in bone samples using micro and nano-X-ray fluorescence spectrometry

DOI: 10.1016/j.apradiso.2019.04.033 DOI Help

Authors: C. Streli (Atominstitut, TU Wien) , M. Rauwolf (Atominstitut, TU Wien) , A. Turyanskaya (Atominstitut, TU Wien) , D. Ingerle (Atominstitut, TU Wien) , P. Wobrauschek (Atominstitut, TU Wien)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Applied Radiation And Isotopes

State: Published (Approved)
Published: April 2019

Abstract: Our group employs micro- and nano-X-ray fluorescence spectrometry (XRF) for the investigation of bone tissue. The manuscript presents the results of 3 various projects, in which spatial distribution of trace elements in bone samples was studied. The first study investigated the distribution of the elemental constituents of Mg-based implants at various stages of the degradation process in surrounding bone tissue with a focus on magnesium (Mg) and yttrium (Y). The analysis was performed in laboratory of Atominstitut using a special micro-XRF spectrometer for light element detection. The second study is devoted to the spatial distribution of Zn in high-grade sclerosing osteosarcoma mapped by confocal synchrotron radiation induced micro-XRF. Tumour zinc levels were compared with adjacent normal tissue. For discrimination between healthy and diseased bone quantitative backscattered electron imaging was used. The third experiment demonstrates the performance of synchrotron radiation induced nano-XRF with beam size of about 500 nm for bone tissue investigation. Special emphasis is set to advantages of micro- and nano-XRF in bone analysis as well as overcoming possible limitations.

Diamond Keywords: Bone

Subject Areas: Biology and Bio-materials


Instruments: B16-Test Beamline

Added On: 07/05/2019 11:22

Discipline Tags:

Life Sciences & Biotech

Technical Tags:

Diffraction