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Nanofocused synchrotron X-ray absorption studies of the intracellular redox state of an organometallic complex in cancer cells

DOI: 10.1039/C9CC01675A DOI Help

Authors: Carlos Sanchez-cano (University of Warwick) , Diego Gianolio (Diamond Light Source) , Isolda Romero-canelon (University of Warwick,) , Remi Tucoulou (ESRF) , Peter J. Sadler (University of Warwick)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Chemical Communications , VOL 109

State: Published (Approved)
Published: May 2019

Open Access Open Access

Abstract: Synchrotron nanoprobe X-ray absorption (XAS) studies of a potent organo-osmium arene anticancer complex in ovarian cancer cells at subcellular resolution allow detection and quantification of both OsII and OsIII species, which are distributed heterogeneously in different areas of the cells.

Subject Areas: Chemistry, Biology and Bio-materials

Instruments: I18-Microfocus Spectroscopy

Other Facilities: ESRF