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Metal and organic templates together control the size of covalent macrocycles and cages

DOI: 10.1021/jacs.9b06182 DOI Help

Authors: Roy Lavendomme (University of Cambridge) , Tanya K. Ronson (University of Cambridge) , Jonathan R. Nitschke (University of Cambridge)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Journal Of The American Chemical Society

State: Published (Approved)
Published: July 2019
Diamond Proposal Number(s): 15768

Abstract: Covalent macrocycles and three-dimensional cages were prepared by the self-assembly of di- or tri-topic anilines and 2,6-diformylpyridine subcomponents around palladium(II) templates. The resulting 2,6-bis(imino)pyridyl-PdII motif contains a tridentate ligand leaving a free coordination site on the PdII centers, which points inward. The binding of ligands to the free coordination sites in these assemblies was found to alter the product stability, and multi-topic ligands could be used to control product size. Multi-topic ligands also bridged metallomacrocycles to form higher-order supramolecular assemblies, which were characterized via NMR spectroscopy, mass spectrometry and X-ray crystallography. An efficient method was developed to reduce the imine bonds to secondary amines, leading to fully organic covalent macrocycles and cages, which were inaccessible through other means.

Subject Areas: Chemistry


Instruments: I19-Small Molecule Single Crystal Diffraction