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Interaction of a tripeptide with titania surfaces: RGD adsorption on rutile TiO2(110) and model dental implant surfaces

DOI: 10.1016/j.msec.2019.110030 DOI Help

Authors: Michael Wagstaffe (University of Manchester) , Hadeel Hussain (Diamond Light Source) , Mark Taylor (Diamond Light Source) , Matthew Murphy (The University of Manchester) , Nikolaos Silikas (The University of Manchester) , Andrew G. Thomas (University of Manchester)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Materials Science And Engineering: C

State: Published (Approved)
Published: July 2019

Abstract: The adsorption of peptides on metal oxides is an area of significant interest, both fundamentally and in a number of technologically important areas. These range from the integration of biomaterials in the body, to denaturation of protein therapeutics and the use of biomolecules and bioinspired materials in synthesis and stabilization of novel nanomaterials. Here we present a study of the tripeptide arginylglycylaspartic acid (RGD) on the surfaces of vacuum-prepared single crystalline TiO2(110), pyrocatechol-capped TiO2(110), and model SLA and SLActive dental implant samples. X-ray Photoelectron Spectroscopy and Scanning Tunneling Microscopy show that the RGD adsorption mode on the single crystal is consistent with bonding through the deprotonated carboxylate groups of the peptide to surface Ti atoms of the substrate. Despite the increased hydrophobicity of the pyrocatechol-capped TiO2(110) surface RGD adsorption from solution increases following this surface treatment. RGD adsorption on SLA and SLActive surfaces shows that the SLActive surface has a greater uptake of RGD. The RGD uptake on the pyrocatechol capped single crystal and the model implant surfaces suggest that the ease with which surface contaminant hydrocarbons are removed from the surface has a greater influence on peptide adsorption than hydrophobicity/hydrophilicity of the surface.

Subject Areas: Materials

Instruments: I07-Surface & interface diffraction

Added On: 31/07/2019 11:59

Discipline Tags:

Surfaces Biomaterials Dentistry Physics Health & Wellbeing Materials Science Life Sciences & Biotech

Technical Tags:

Spectroscopy X-ray Photoelectron Spectroscopy (XPS)