Multi-scale and multi-modal investigation of the onset of mineralization in embryonic mouse long bones

Authors: Sophie Le Cann (Lund University) , Isabella Silva Barreto (Lund University) , Adam Urga (Lund University) , Vivien Sotiriou (Imperial College London) , Aurelie Levillain (Imperial College London) , Mikael J. Turunen (Lund University; University of Eastern Finland) , Marianne Liebi (MAX IV Laboratory) , Andrew J. Bodey (Diamond Light Source) , Ulf Johansson (MAX IV Laboratory) , Niamh Nowlan (Imperial College London) , Hanna Isaksson (Lund University)
Co-authored by industrial partner: No

Type: Conference Paper
Conference: ORS 2019
Peer Reviewed: No

State: Published (Approved)
Published: February 2019

Abstract: Long bone mineralization develops through endochondral ossification, where a cartilage template is replaced by mineralized bone. From the primary ossification center in the middle of the long bone, mineralization progresses during growth in both directions at the growth plates. While the basic sequence of bone formation during embryogenesis is known, almost no detailed characterization of early developing and new mineralized tissue and bone has been conducted. This project aims to characterize the most important steps in early mineralization of the skeleton, using a multi-scale and multi-modal approach. More specifically, bone mineralization in the embryonic mouse humerus is studied from the anatomical down to the compositional and structural level using a range of novel high-resolution imaging methods based on high-intensity x-rays (synchrotron).

Subject Areas: Biology and Bio-materials

Instruments: I13-2-Diamond Manchester Imaging