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Cation-induced chirality in a bifunctional metal-organic framework for quantitative enantioselective recognition

DOI: 10.1038/s41467-019-13090-9 DOI Help

Authors: Zongsu Han (Nankai University) , Kunyu Wang (Nankai University) , Yifan Guo (Nankai University) , Wenjie Chen (Nankai University) , Jiale Zhang (Nankai University) , Xinran Zhang (University of Manchester) , Giuliano Siligardi (Diamond Light Source) , Sihai Yang (University of Manchester) , Zhen Zhou (Nankai University) , Pingchuan Sun (Nankai University) , Wei Shi (Nankai University) , Peng Cheng (Nankai University)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Nature Communications , VOL 10

State: Published (Approved)
Published: November 2019
Diamond Proposal Number(s): 20293

Open Access Open Access

Abstract: The integration of luminescence and chirality in easy-scalable metal-organic frameworks gives rise to the development of advanced luminescent sensors. To date, the synthesis of chiral metal-organic frameworks is poorly predictable and their chirality primarily originates from components that constitute the frameworks. By contrast, the introduction of chirality into the pores of metal-organic frameworks has not been explored to the best of our knowledge. Here, we demonstrate that chirality can be introduced into an anionic Zn-based metal-organic framework via simple cation exchange, yielding dual luminescent centers comprised of the ligand and Tb3+ ions, accompanied by a chiral center in the pores. This bifunctional material shows enantioselectivity luminescent sensing for a mixture of stereoisomers, demonstrated for Cinchonine and Cinchonidine epimers and amino alcohol enantiomers, from which the quantitative determination of the stereoisomeric excess has been obtained. This study paves a pathway for the design of multifunctional metal-organic framework systems as a useful method for rapid sensing of chiral molecules.

Journal Keywords: Coordination chemistry; Supramolecular chemistry

Subject Areas: Chemistry, Materials

Instruments: B23-Circular Dichroism , I19-Small Molecule Single Crystal Diffraction