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Induction of non-lamellar phases in archaeal lipids at high temperature and high hydrostatic pressure by apolar polyisoprenoids

DOI: 10.1016/j.bbamem.2019.183130 DOI Help

Authors: Marta Salvador Castell (Université de Lyon) , Nicholas J. Brooks (Imperial College London) , Judith Peters (Université Grenoble Alpes; Institut Laue Langevin) , Philippe Oger (Université de Lyon)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Biochimica Et Biophysica Acta (bba) - Biomembranes

State: Published (Approved)
Published: November 2019

Abstract: It is now well established that cell membranes are much more than a barrier that separate the cytoplasm from the outside world. Regarding membrane's lipids and their self-assembling, the system is highly complex, for example, the cell membrane needs to adopt different curvatures to be functional. This is possible thanks to the presence of non-lamellar-forming lipids, which tend to curve the membrane. Here, we present the effect of squalane, an apolar isoprenoid molecule, on an archaea-like lipid membrane. The presence of this molecule provokes negative membrane curvature and forces lipids to self-assemble under inverted cubic and inverted hexagonal phases. Such non-lamellar phases are highly stable under a broad range of external extreme conditions, e.g. temperatures and high hydrostatic pressures, confirming that such apolar lipids could be included in the architecture of membranes arising from cells living under extreme environments.

Diamond Keywords: Archaea

Subject Areas: Biology and Bio-materials


Instruments: I22-Small angle scattering & Diffraction

Added On: 20/11/2019 10:26

Discipline Tags:

Soft condensed matter physics Biophysics Life Sciences & Biotech

Technical Tags:

Scattering Small Angle X-ray Scattering (SAXS)