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Optimizing contrast and spatial resolution in hard x-ray tomography of medically relevant tissues
Authors:
Griffin
Rodgers
(University of Basel)
,
Georg
Schulz
(University of Basel)
,
Hans
Deyhle
(University of Basel)
,
Willy
Kuo
(University of Basel; University of Zurich)
,
Christoph
Rau
(Diamond Light Source)
,
Timm
Weitkamp
(Synchrotron Soleil)
,
Bert
Muller
(University of Basel)
Co-authored by industrial partner:
No
Type:
Journal Paper
Journal:
Applied Physics Letters
, VOL 116
State:
Published (Approved)
Published:
January 2020
Diamond Proposal Number(s):
19829
,
20746
Abstract: Hard x-ray tomography with Paganin's widespread single-distance phase retrieval filter improves the contrast-to-noise ratio (CNR) while reducing spatial resolution (SR). We demonstrate that a Gaussian filter provided larger CNR at high SR with interpretable density measurements for two medically relevant soft tissue samples. Paganin's filter produced larger CNR at low SR, though a priori assumptions were generally false and image quality gains diminish for CNR > 1. Therefore, simple absorption measurements of low-Z specimens combined with Gaussian filtering can provide improved image quality and model-independent density measurements compared to single-distance phase retrieval.
Journal Keywords: Organs; Tomography; Density measurement; X-ray imaging; Synchrotron radiation; Hard X-rays; Linear filters
Subject Areas:
Technique Development,
Biology and Bio-materials
Instruments:
I13-2-Diamond Manchester Imaging