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Non-lamellar liquid crystalline nanocarriers for thymoquinone encapsulation
DOI:
10.3390/molecules25010016
Authors:
Anan
Yaghmur
(University of Copenhagen)
,
Boi Vi
Tran
(University of Copenhagen)
,
Seyed Moein
Moghimi
(Newcastle University; University of Colorado Anschutz Medical Campus)
Co-authored by industrial partner:
No
Type:
Journal Paper
Journal:
Molecules
, VOL 25
State:
Published (Approved)
Published:
December 2019
Diamond Proposal Number(s):
17191

Abstract: Owing to their unique structural features, non-lamellar liquid crystalline nanoparticles comprising cubosomes and hexosomes are attracting increasing attention as versatile investigative drug carriers. Background: Depending on their physiochemical characteristics, drug molecules on entrapment can modulate and reorganize structural features of cubosomes and hexosomes. Therefore, it is important to assess the effect of guest molecules on broader biophysical characteristics of non-lamellar liquid crystalline nanoparticles, since drug-induced architectural, morphological, and size modifications can affect the biological performance of cubosomes and hexosomes. Methods: We report on alterations in morphological, structural, and size characteristics of nanodispersions composed from binary mixtures of glycerol monooleate and vitamin E on thymoquinone (a molecule with wide therapeutic potentials) loading. Results: Thymoquinone loading was associated with a slight increase in the mean hydrodynamic nanoparticle size and led to structural transitions from an internal biphasic feature of coexisting inverse cubic Fd3m and hexagonal (H2) phases to an internal inverse cubic Fd3m phase (micellar cubosomes) or an internal inverse micellar (L2) phase (emulsified microemulsions, EMEs). We further report on the presence of “flower-like” vesicular populations in both native and drug-loaded nanodispersions. Conclusions: These nanodispersions have the potential to accommodate thymoquinone and may be considered as promising platforms for the development of thymoquinone nanomedicines.
Journal Keywords: drug encapsulation; inverse cubic Fd3m phase; inverse hexagonal phase; nanodispersions; micellar cubosomes; nanoparticle tracking analysis; synchrotron small-angle scattering
Subject Areas:
Biology and Bio-materials,
Medicine
Instruments:
I22-Small angle scattering & Diffraction
Added On:
31/01/2020 10:00
Documents:
molecules-25-00016-v2.pdf
Discipline Tags:
Drug Delivery
Biomaterials
Health & Wellbeing
Materials Science
Nanoscience/Nanotechnology
Life Sciences & Biotech
Technical Tags:
Scattering
Small Angle X-ray Scattering (SAXS)