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An Adaptable Peptide-Based Porous Material

DOI: 10.1126/science.1190672 DOI Help
PMID: 20798314 PMID Help

Authors: Jeremy Rabone (University of Liverpool) , Yan-feng Yue (University of Liverpool) , Sam Chong (University of Liverpool) , Kyriakos Stylianou (University of Liverpool) , John Bacsa (University of Liverpool) , Darren Bradshaw (University of Liverpool) , George Darling (University of Liverpool) , Neil Berry (University of Liverpool) , Yaroslav Khimyak (University of Liverpool) , Alexey Ganin (University of Liverpool) , Paul Wiper (University of Liverpool) , John Claridge (University of Liverpool) , Matthew Rosseinsky (University of Liverpool)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Science , VOL 329 (5995) , PAGES 1053-1057

State: Published (Approved)
Published: August 2010
Diamond Proposal Number(s): 1732

Abstract: Porous materials find widespread application in storage, separation, and catalytic technologies. We report a crystalline porous solid with adaptable porosity, in which a simple dipeptide linker is arranged in a regular array by coordination to metal centers. Experiments reinforced by molecular dynamics simulations showed that low-energy torsions and displacements of the peptides enabled the available pore volume to evolve smoothly from zero as the guest loading increased. The observed cooperative feedback in sorption isotherms resembled the response of proteins undergoing conformational selection, suggesting an energy landscape similar to that required for protein folding. The flexible peptide linker was shown to play the pivotal role in changing the pore conformation.

Journal Keywords: Metal-Organic Frameworks; Solid-State Nmr; Adsorption; Dimensions; Dipeptides; Complexes; Crystals

Subject Areas: Chemistry, Materials


Instruments: I11-High Resolution Powder Diffraction