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Improved acid resistance of a metal-organic cage enables cargo release and exchange between hosts

DOI: 10.1002/anie.202001059 DOI Help

Authors: Lin Xu (University of Cambridge) , Dawei Zhang (University of Cambridge) , Tanya Ronson (University of Cambridge) , Jonathan Nitschke (University of Cambridge)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Angewandte Chemie International Edition

State: Published (Approved)
Published: February 2020
Diamond Proposal Number(s): 15768

Abstract: Here we introduce the use of di(2‐pyridyl)ketone in subcomponent self‐assembly. When combined with a flexible triamine and zinc bis(trifluoromethylsulfon)imide, this ketone formed a new Zn 4 L 4 tetrahedron 1 bearing twelve uncoordinated pyridyl units around its metal‐ion vertices. The acid stability of 1 was found to be greater than that of the analogous tetrahedron 2 built from 2‐formylpyridine. Intriguingly, the peripheral presence of additional pyridine rings in 1 resulted in distinct guest binding behavior from that of 2 , affecting guest scope as well as binding affinities. The different stabilities and guest affinities of capsules 1 and 2 enabled the design of systems whereby different cargoes could be moved between cages using acid and base as chemical stimuli.

Journal Keywords: metal-organic cage; acid resistance; cargo delivery; supramolecular chemistry

Subject Areas: Chemistry

Instruments: I19-Small Molecule Single Crystal Diffraction

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