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Investigation of bone matrix composition, architecture and mechanical properties reflect structure-function relationship of cortical bone in glucocorticoid induced osteoporosis

DOI: 10.1016/j.bone.2020.115334 DOI Help

Authors: Li Xi (Beijing Institute of Technology; Queen Mary University of London; Diamond Light Source) , Yu Song (North Carolina State University) , Wenwang Wu (Beijing Institute of Technology; Massachusetts Institute of Technology) , Zhaoliang Qu (Beijing Institute of Technology) , Jiawei Wen (Beijing Institute of Technology) , Binbin Liao (Beijing Institute of Technology) , Ran Tao (Beijing Institute of Technology) , Jingran Ge (Beijing Institute of Technology) , Daining Fang (Beijing Institute of Technology; Peking University)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Bone

State: Published (Approved)
Published: March 2020

Abstract: Glucocorticoid induced osteoporosis (GIOP) is the most common negative consequence of long-term glucocorticoid treatment, leading to increased fracture risk followed by loss of mobility and high mortality risk. These biologically induced changes in bone quality at molecular level lead to changes both in bone matrix architecture and bone matrix composition. However, the quantitative details of changes in bone quality - and especially their link to reduced macroscale mechanical properties are still largely missing. In this study, a mouse model for glucocorticoid-induced osteoporosis (GIOP) was used to investigate mechanical and material alterations in bone cortex (natural nanocomposite) at different scale. By combining quantitative backscattered electron (qBSE) imaging, nanoindentation and high brilliance synchrotron X-ray nanomechanical imaging on a genetically modified mouse model of GIOP, we were able to quantify the local indentation modulus, mineralization distribution and the alterations of nanoscale structures and deformation mechanisms in the mid-diaphysis of femur, and relate them to the macroscopic mechanical changes. Our results showed clear and significant changes in terms of material quality of bone at nanoscale and microscale, which manifests itself in development of spatial heterogeneities in mineralization and indentation moduli across the bone organ, with potential implications for increased fracture risk.

Journal Keywords: Glucocorticoid induced osteoporosis; Structure-function relationships; Nanoindentation; Synchrotron X-ray nanomechanical imaging

Subject Areas: Biology and Bio-materials

Instruments: I22-Small angle scattering & Diffraction