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Guest binding drives host redistribution in libraries of CoII4L4 cages

DOI: 10.1002/anie.202004627 DOI Help

Authors: Marion Kieffer (University of Cambridge) , Rana A. Bilbeisi (American University of Beirut) , John D. Thoburn (Randolph Macon College) , Jack K. Clegg (University of Queensland) , Jonathan Nitschke (University of Cambridge)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Angewandte Chemie International Edition

State: Published (Approved)
Published: April 2020
Diamond Proposal Number(s): 6791

Open Access Open Access

Abstract: Two Co II 4 L 4 tetrahedral cages prepared from similar building blocks showed contrasting host‐guest properties. One cage did not bind guests, whereas the second encapsulated a series of anions, due to electronic and geometric effects. When the building blocks of both cages were present during self‐assembly, a library of five CoIILAxLB4‐x cages was formed in a statistical ratio in the absence of guests. Upon incorporation of anions able to interact preferentially with some library members, the products obtained were redistributed in favor of the best anion binders. To quantify the magnitudes of these templation effects, ESI‐MS was used to gauge the effect of each template upon library redistribution.

Journal Keywords: self-assembly; metal-organic cages; host-guest systems; supramolecular library; mass-spectrometry

Subject Areas: Chemistry

Instruments: I19-Small Molecule Single Crystal Diffraction


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