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Edge-subtraction X-ray ptychographic imaging with pink beam synchrotron radiation and a single photon-counting detector

DOI: 10.1038/s41598-020-63161-x DOI Help

Authors: Francesco Brun (University of Trieste; National Institute for Nuclear Physics (INFN) - Trieste division) , Vittorio Di Trapani (University of Siena; National Institute for Nuclear Physics (INFN) - Pisa division) , Darren Batey (Diamond Light Source) , Silvia Cipiccia (Diamond Light Source; University of Strathclyde) , Christoph Rau (Diamond Light Source)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Scientific Reports , VOL 10

State: Published (Approved)
Published: April 2020
Diamond Proposal Number(s): 21555

Open Access Open Access

Abstract: We present here a new method of performing X-ray edge-subtraction ptychographic imaging by combining multiple harmonics from an undulator synchtrotron source and an energy discriminating photon counting detector. Conventionally, monochromatic far-field X-ray ptychography is used to perform edge subtraction through the use of multiple monochromatic energy scans to obtain spectral information for a variety of applications. Here, we use directly the undulator spectrum from a synchrotron source, selecting two separate harmonics post sample using the Pixirad-1/Pixie-III detector. The result is two monochromatic images, above and below an absorption edge of interest. The proposed method is applied to obtain Au L-edge subtraction imaging of a Au-Ni grid test sample. The Au L-edge subtraction is particularly relevant for the identification of gold nanoparticles for biomedical applications. Switching the energy scan mechanism from a mechanical monochromator to an electronic detector threshold allows for faster spectral data collection with improved stability.

Journal Keywords: Imaging and sensing; Imaging techniques; Phase-contrast microscopy

Subject Areas: Technique Development

Instruments: I13-1-Coherence