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Isotopic control over self-assembly in supramolecular gels

DOI: 10.1021/acs.langmuir.0c01552 DOI Help

Authors: Kate Mcauley (University of Glasgow) , Han Wang (Johns Hopkins University) , Ana M. Fuentes-caparros (University of Glasgow) , Lisa Thomson (University of Glasgow) , Nikul Khunti (Diamond Light Source) , Nathan P. Cowieson (Diamond Light Source) , Honggang Cui (Johns Hopkins University) , Annela Seddon (University of Bristol) , Dave J. Adams (University of Glasgow)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Langmuir

State: Published (Approved)
Published: July 2020

Open Access Open Access

Abstract: It is common to switch between H2O and D2O when examining peptide-based systems with the assumption being that there are no effects from this change. Here, we describe the effect of changing from H2O to D2O in a number of low molecular weight dipeptide-based gels. Gels are formed by decreasing the pH. In most cases, there is little dif-ference in the structures formed at high pH, but this is not universally true. On lowering the pH, the ki-netics of gelation are affected and, in some cases, the structures underpinning the gel network are dif-ferent. Where there are differences in the self-assembled structures, the resulting gel properties are different. We therefore show isotopic control over gel properties is possible.

Subject Areas: Chemistry

Instruments: B21-High Throughput SAXS