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The influence of loops on the binding of the [Ru(phen) 2 dppz] 2+ light-switch compound to i-motif DNA structures revealed by time-resolved spectroscopy

DOI: 10.1039/D0CC03702H DOI Help

Authors: Frederico R. Baptista (University College Dublin) , Stephen J. Devereux (University College Dublin) , Sarah P. Gurung (University of Reading; Diamond Light Source) , James P. Hall (University of Reading) , Igor V. Sazanovich (Central Laser Facility, Rutherford Appleton Laboratory, STFC) , Michael Towrie (Research Complex at Harwell) , Christine J. Cardin (University of Reading) , John A. Brazier (University of Reading) , John M. Kelly (Trinity College Dublin) , Susan J. Quinn (University College Dublin)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Chemical Communications , VOL 10

State: Published (Approved)
Published: July 2020

Abstract: Ultrafast time resolved infrared (TRIR) is used to report on the binding site of the “light-switch” complex [Ru(phen)2(dppz)]2+ 1 to i-motif structures in solution. Detailed information is provided due to perturbation of the local base vibrations by a ‘Stark-like’ effect which is used to establish the contribution of thymine base loop interactions to the binding site of 1 in this increasingly relevant DNA structure.

Subject Areas: Chemistry

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Added On: 27/07/2020 14:43

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Chemistry Organic Chemistry

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