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Metastable crystalline phase formation in deep eutectic systems revealed by simultaneous synchrotron XRD and DSC

DOI: 10.1039/D0CC04696E DOI Help

Authors: Charlie Hall (University of Bristol) , Jason Potticary (University of Bristol) , Victoria Hamilton (University of Bristol) , Simon Gaisford (University College London) , Asma Buanz (University College London) , Simon Hall (University of Bristol)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Chemical Communications

State: Published (Approved)
Published: August 2020
Diamond Proposal Number(s): 23947

Open Access Open Access

Abstract: The phase behaviour of various deep eutectic systems was analysed using concurrent synchrotron powder X-ray diffraction and differential scanning calorimetry. Deep eutectic systems containing the pharmaceuticals metacetamol, 2-ethoxybenzamide or benzamide as binary mixtures with phenol revealed new crystalline phases melting either before or with crystals of phenol, highlighting their lower stabilities. Furthermore, in the phenol:2-ethoxybenzamide system it was shown that multiple metastable phases can form, highlighting the potential for the separation of a hierarchy of crystal structures with differing stabilities from eutectic systems. Through these experiments, we strengthen the idea that eutectic systems can be described by understanding the formation and stabilities of metastable co-crystalline structures. These novel results lead to a deeper understanding of the structure and thermodynamics of deep eutectic solvents, with relevance for analagous systems across materials science.

Subject Areas: Chemistry

Instruments: I12-JEEP: Joint Engineering, Environmental and Processing

Added On: 13/08/2020 08:34


Discipline Tags:

Chemistry Organic Chemistry

Technical Tags:

Diffraction X-ray Powder Diffraction