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Peptide nanotubes self-assembled from leucine-rich alpha helical surfactant-like peptides

DOI: 10.1039/D0CC04299D DOI Help

Authors: Valeria Castelletto (University of Reading) , Jani Seitsonen (Aalto University) , Janne Ruokolainen (Aalto University) , Cristian Piras (University of Reading) , Rainer Cramer (University of Reading) , Charlotte J. C. Edwards-gayle (Diamond Light Source) , Ian W. Hamley (Diamond Light Source)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Chemical Communications , VOL 369

State: Published (Approved)
Published: September 2020
Diamond Proposal Number(s): 22925

Open Access Open Access

Abstract: The designed arginine-rich surfactant-like peptide R3L12 (arginine3–leucine12) is shown to form a remarkable diversity of self-assembled nanostructures in aqueous solution, depending on pH, including nanotubes, mesh-like tubular networks in three-dimensions and square planar arrays in two-dimensions. These structures are built from α-helical antiparallel coiled–coil peptide dimers arranged perpendicular to the nanotube axis, in a “cross-α” nanotube structure. The aggregation behavior is rationalized based on the effects of dimensionality, and the balance of hydrophobic and electrostatic interactions. The nanotube and nanomesh structures display arginine at high density on their surfaces, which may be valuable for future applications.

Subject Areas: Chemistry

Instruments: B21-High Throughput SAXS