Publication

Development and research on new types of biocompatible alloys

Authors: Michaela Sulikova (Pavol Jozef Safarik University in Kosice)
Co-authored by industrial partner: No

Type: Thesis

State: Published (Approved)
Published: August 2020
Diamond Proposal Number(s): 17628 , 21642

Abstract: With an increasingly aging population and improvement of living standards, there is a rising demand for new biomaterials to replace or repair structural (load-bearing) components of the human body. Nowadays, stainless steels, titanium and its alloys are commonly used for implant devices that replace a patient’s hard tissues. However, these implants are composed of harmful elements like Al, Mn, Cr, V, Co, Ni causing inflammation response in surrounding tissue. Another problem is corrosion. Corrosion is caused by the contact of the metallic implant with human fluids. Therefore it is needed to develop alloys which should have properties like the human bone and at the same time better in comparison with current metallic bone replacements. The theoretical part of this work consists of a comprehensive literature review of present metallic and new biocompatible alloys supplemented with the latest knowledge concerning harmfulness to the human body. The theoretical part of this work consists of a comprehensive literature review of present metallic and new biocompatible alloys supplemented with the latest knowledge concerning harmfulness to the human body. he first part of the thesis experimental is focused on the preparation and characterization of new types of metallic biocompatible materials based on Ti(100-x)/100Six/100 alloys (x = 67, 50, 44, 37.5 and 25 at. %), Ti(100-x)/100Snx/100 alloys (x = 45.5, 37.5, 33, and 25 at. %), Zr(100-x)/100Six/100 alloys (x = 67, 50, 44, 40, 33 and 25 at. %) and (TiZr)0.625Si0.375. On all the material samples properties such as density, microstructure, phase composition, local mechanical properties were determined together with cytotoxicity tests and observation of live-dead stained MC3T3E1 cells on their surfaces. The Ti-Si sample was prepared also in the form of bulk disc compacted by spark plasma sintering method. Its surface was covered by biodegradable hydrogel via photopolymerization reaction in order to improve its live body compatibility. The second part of my thesis deals with development of brand new biodegradable Mg-Zn-Sr and Mg-Zn-Ca alloys. The samples were designed for temporary surgical replacements prepared in Sr and Ca concentrations ranging from 6 to 8 at.%. by the melt spinning technique. Densities, elastic modulus, nano-hardness, thermal stability and dissociation rate were measured on the samples. Outcomes of the research are knowledge based for our development of high alloyed systems with tailored properties.

Journal Keywords: biocompatibility; biocompatible materials; implants; Ti-Si; Ti-Sn; Zr-Si; Ti-Zr-Si; biodegradable alloys; Mg-Zn-Sr; Mg-Zn-Ca

Subject Areas: Materials, Biology and Bio-materials


Instruments: I12-JEEP: Joint Engineering, Environmental and Processing

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