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A multiscale study of structural and compositional changes in a natural nanocomposite: osteoporotic bone with chronic endogenous steroid excess

DOI: 10.1016/j.bone.2020.115666 DOI Help

Authors: Li Xi (Beijing Institute of Technology; Queen Mary University of London; Diamond Light Source) , Yi Zhang (Institution of High Energy Physics, Chinese Academy of Science) , Himadri Gupta (Queen Mary University of London) , Nick Terrill (Diamond Light Source) , Pan Wang (Beijing Institute of Technology) , Tian Zhao (Beijing Institute of Technology) , Daining Fang (Beijing Institute of Technology; Peking University)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Bone

State: Published (Approved)
Published: September 2020

Abstract: Glucocorticoid (or steroid) induced osteoporosis (GIOP) is the leading form of secondary osteoporosis, affecting up to 50% of patients receiving chronic glucocorticoid therapy. Bone quantity (bone mass) changes in GIOP patients alone are inadequate to explain the increased fracture risk, and bone material changes (bone quality) at multiple levels have been implicated in the reduced mechanics. Quantitative analysis of specific material-level changes is limited. Here, we combined multiscale experimental techniques (scanning small/wide-angle X-ray scattering/diffraction, backscattered electron imaging, and X-ray radiography) to investigate these changes in a mouse model (Crh−120/+) with chronic endogenous steroid production. Nanoscale degree of orientation, the size distribution of mineral nanocrystals in the bone matrix, the spatial map of mineralisation on the femoral cortex, and the microporosity showed significant changes between GIOP and the control, especially in the endosteal cortex. Our work can provide insight into the altered structure-property relationship leading to lowered mechanical properties in GIOP.

Journal Keywords: Bone-quality Changes; Steroid-induced Osteoporosis; Synchrotron X-ray Nanomechanical Imaging; Backscattered Electron Imaging

Subject Areas: Biology and Bio-materials

Instruments: I22-Small angle scattering & Diffraction

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